| Title: |
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort |
| Authors: |
Shaw, Dominick; Sousa, Ana; Fowler, Stephen; Fleming, Louise; Roberts, Graham; Corfield, Julie; Pandis, Ioannis; Bansal, Aruna; Bel, Elisabeth; Auffray, Charles; Compton, Chris; Bisgaard, Hans; Bucchioni, Enrica; Caruso, Massimo; Chanez, Pascal; Dahlén, Barbro; Dahlén, Sven-Erik; Dyson, Kerry; Frey, Urs; Geiser, Thomas; Gerhardsson de Verdier, Maria; Gibeon, David; Guo, Yi-Ke; Hashimoto, Simone; Hedlin, Gunilla; Jeyasingham, Elizabeth; Hekking, Pieter-Paul; Higenbottam, Tim; Horváth, Ildikó; Knox, Alan; Krug, Norbert; Erpenbeck, Veit; Larsson, Lars; Lazarinis, Nikos; Matthews, John; Middelveld, Roelinde; Montuschi, Paolo; Musial, Jacek; Myles, David; Pahus, Laurie; Sandström, Thomas; Seibold, Wolfgang; Singer, Florian; Strandberg, Karin; Vestbo, Jorgen; Vissing, Nadja; von Garnier, Chris; Adcock, Ian; Wagers, Scott; Rowe, Anthony; Howarth, Peter; Wagener, Ariane; Djukanovic, Ratko; Sterk, Peter; Chung, Kian Fan; Pison, Christophe |
| Contributors: |
Unité de Génétique Moléculaire et de Biologie du Développement; Centre National de la Recherche Scientifique (CNRS); Service des Maladies Respiratoires Marseille; Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Timone CHU - APHM (TIMONE)-Hôpital Nord CHU - APHM; Karolinska Institutet = Karolinska Institute Stockholm; Fraunhofer Institute for Toxicology and Experimental Medicine (Fraunhofer ITEM); Fraunhofer (Fraunhofer-Gesellschaft); Department of Clinical Neuroscience; Alliance Global Water Adaptation; Department of Computer Engineering (DAUIN); Politecnico di Torino = Polytechnic of Turin (Polito); Department of Medicine; Uniwersytet Jagielloński w Krakowie = Jagiellonian University = Université Jagellon de Cracovie (UJ); Assistance Publique - Hôpitaux de Marseille (APHM); Wythenshawe Hospital; Northwest Lung Centre; Airway Disease Section, National Heart and Lung Institute; Imperial College London; Laboratoire de bioénergétique fondamentale et appliquée (LBFA); Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM); CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); U-BIOPRED is supported through an Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115010, resources of which are composed of financial contribution from the European Union's Seventh Framework Programme (FP7/2007–2013); IMI funded eTRIKS project (EU Grant Code No.115446); EFPIA companies’ in kind contribution (www.imi.europa.eu) |
| Source: |
ISSN: 0903-1936. |
| Publisher Information: |
CCSD; European Respiratory Society |
| Publication Year: |
2015 |
| Collection: |
Université Grenoble Alpes: HAL |
| Subject Terms: |
[SDV]Life Sciences [q-bio]; [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Description: |
International audience ; U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1183/13993003.00779-2015 |
| Availability: |
https://hal.univ-grenoble-alpes.fr/hal-01969506; https://doi.org/10.1183/13993003.00779-2015 |
| Accession Number: |
edsbas.177D8CC2 |
| Database: |
BASE |