| Title: |
P-1647. Duration of SARS-CoV-2 Detection with Rapid Antigen Tests and Nucleic Acid Amplification Tests in a 2024 Nursing Home Resident Cohort |
| Authors: |
Jackson, Katelin; Hernandez, Alfonso; Reeves, Majerle; Lopez, Velma K; Harris, Tiffany; Abul, Yasin; Canaday, David; Crnich, Christopher J; LeClair, Lindsay B; Fuller, Samantha; Fridkin, Scott; Furuno, Jon P; Gravenstein, Stefan; Handler, Steven; Harcourt, Jennifer L; Healy, Jessica; Lipsitch, Marc; Lutgring, Joseph D; Meece, Jennifer K; Mellis, Alexandra; Mody, Lona; Nace, David A; Paul, Prabasaj; Rebolledo, Paulina; Kirking, Hannah L; Slayton, Rachel; Reddy, Sujan; Katz, Morgan |
| Source: |
Open Forum Infectious Diseases ; volume 13, issue Supplement_1 ; ISSN 2328-8957 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2026 |
| Description: |
Background Nursing home (NH) residents are at high risk of contracting and having adverse outcomes from SARS-CoV-2. Based on culture positivity CDC currently recommends 10-day transmission-based precautions; greater understanding of the duration of SARS-CoV-2 detection with rapid antigen tests (RAT) and nucleic acid amplification tests (NAAT), can further guide testing and isolation recommendations to reduce transmission. In a 2023 NH cohort with daily testing, the median duration of SARS-CoV-2 detection among NH residents was six days for RAT and 11 days for NAAT. We update estimates of SARS-CoV-2 detection duration in a 2024 cohort of NH residents to inform prevention efforts.Figure 1:Kaplan-Meier analysis was restricted to residents with ≥4 RAT (n = 88) or NAAT (n = 84). A resident could be in both RAT and NAAT survival curves. The median duration of SARS-CoV-2 detection with RAT was seven days and the median duration of SARS-CoV-2 detection with NAAT was 14 days. Methods We collected data on NH residents tested for SARS-CoV-2 with RAT and NAAT in 17 NHs across eight states. Residents could enroll upon a positive SARS-CoV-2 RAT or NAAT followed by paired nasal specimen collection every 3-5 days for up to 30 days. We abstracted resident clinical characteristics from available medical records. We used Kaplan-Meier (KM) survival analysis to estimate the time from first positive (day 0) to first negative. We restricted analyses to residents with ≥ 4 RAT or NAAT to capture the duration of SARS-CoV-2 positivity; residents could be in both RAT and NAAT survival curves. We used Greenwood’s formula to calculate 95% confidence intervals (CI). Results We enrolled 121 residents with a positive SARS-CoV-2 test, of whom 87 (72%) were vaccinated. Eighty-five participants (70%) had a Charlson Comorbidity Index score ≥5. Sixty-eight participants received antivirals (n=36 [53%] molnupiravir; n=28 [41%] nirmatrelvir/ritonavir; n=4 [6%] remdesivir). The KM analysis included 88 (73%) and 84 (69%) residents with ≥ 4 RAT ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ofid/ofaf695.1822 |
| Availability: |
https://doi.org/10.1093/ofid/ofaf695.1822; https://academic.oup.com/ofid/article-pdf/13/Supplement_1/ofaf695.1822/66355001/ofaf695.1822.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.17B9BF91 |
| Database: |
BASE |