| Title: |
Aortic valve-sparing root operation in patients with Marfan and Loeys-Dietz syndrome |
| Authors: |
Yildiz, Murat; Werdecker, Victoria; Nucera, Maria; Mosbahi, Selim; Goel, Nicholas; Berezowski, Mikolaj; Lawrence, Kendall; Kapoor, Sankrit; Kreibich, Maximilian; Berger, Tim; Szeto, Wilson Y.; Siepe, Matthias; Czerny, Martin; Schönhoff, Florian; Desai, Nimesh D. |
| Source: |
The annals of thoracic surgery. - 121, 2 (2026) , 338-345, ISSN: 0003-4975 |
| Publication Year: |
2026 |
| Collection: |
University of Freiburg: FreiDok |
| Description: |
BACKGROUND The objective of this study was to evaluate the mid-term outcomes of valve-sparing aortic root replacement (VSRR) in patients with Marfan (MFS) and Loeys-Dietz syndrome (LDS). Additionally, we analyzed operative factors, including the impact of graft selection. METHODS All patients with either MFS (158, 84%) or LDS (30, 16%) who underwent VSRR were included in a retrospective analysis from a transatlantic registry. RESULTS Out of 188 patients with VSRR, ten (5%) required reoperation on the aortic valve (7 MFS and 3 LDS, HR for LDS: 3.25, p = 0.078). Freedom from aortic valve reoperation at 10 years was 94% for MFS and 87% for LDS. 21 patients (11%, 19 MFS and 2 LDS) developed aortic valve regurgitation ≥ 2 (HR LDS: 0.78, p = 0.755). One patient died three days after a severe stroke and 7 patients died during follow-up (7 MFS and 1 LDS, HR LDS: 1.82, p = 0.595). During follow-up, 22 patients required an aortic reintervention (19 MFS and 3 LDS, p = 0.752). Patients with a Valsalva graft experienced significantly less total aortic reinterventions compared to those with a straight graft (HR for Valsalva graft: 0.04, p < 0.001). CONCLUSIONS VSRR shows excellent mid-term outcomes in patients with MFS and LDS. There are no outcome differences between patients with MFS compared to LDS. The use of a Valsalva graft may be considered to reduce aortic reintervention rates in patients with MFS and LDS. |
| Document Type: |
article in journal/newspaper |
| File Description: |
pdf |
| Language: |
English |
| Relation: |
https://freidok.uni-freiburg.de/data/270129 |
| DOI: |
10.1016/j.athoracsur.2025.07.025 |
| Availability: |
https://freidok.uni-freiburg.de/data/270129; https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2701297; https://doi.org/10.1016/j.athoracsur.2025.07.025; https://freidok.uni-freiburg.de/dnb/download/270129 |
| Rights: |
free |
| Accession Number: |
edsbas.17D73AE6 |
| Database: |
BASE |