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Trung N Tran,1 Stephanie Chen,1 Benjamin Emmanuel,1 Alan Altraja,2,3 Arnaud Bourdin,4,5 Chau-Chyun Sheu,6,7 Ming-Ju Tsai,6,7 Flavia CL Hoyte,8 Anna Quinton,9 Bill Cook,1 Lakmini Bulathsinhala,10 William Henley,10,11 Celine Yun Yi Goh,10,12 Yang Liu,10 Cono Ariti,10,12 Victoria Carter,10,12 David B Price10,12,13 On behalf of the CLEAR Study Working Group1Respiratory and Immunology, BioPharmaceuticals Medical, AstraZeneca, Gaithersburg, MD, USA; 2Department of Pulmonary Medicine, University of Tartu, Tartu, Estonia; 3Lung Clinic, Tartu University Hospital, Tartu, Estonia; 4Phymedexp, CNRS, INSERM, University of Montpellier, Montpellier, France; 5Department of Pulmonology and Addiction, University Hospital of Montpellier, Montpellier, France; 6Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; 7Department of Internal Medicine, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 8Division of Allergy and Immunology, National Jewish Health, Denver, CO, USA; 9BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK; 10Observational and Pragmatic Research Institute, Singapore; 11Department of Health and Community Sciences, University of Exeter Medical School, Exeter, UK; 12Optimum Patient Care Global, Cambridge, UK; 13Centre of Academic Primary Care, Division of Applied Health Sciences, University of Aberdeen, Aberdeen, UKCorrespondence: David B Price, Observational and Pragmatic Research Institute, 22 Sin Ming Lane, #06 Midview City, Singapore, 573969, Tel +6531051489, Email dprice@opri.sgBackground: Biologics targeting immunoglobulin E, interleukin (IL)-4/IL-13 or IL-5 signaling are effective at treating severe asthma; however, individual patients’ responses may be suboptimal, leading to therapy switching or stopping. The CLEAR study aimed to assess real-world biologic use patterns and associated clinical outcomes in patients receiving care for severe asthma.Methods: CLEAR was a ... |