| Title: |
P4416 Racial differences in weight loss and its impact on cardiovascular outcomes after bariatric surgery in patients with morbid obesity |
| Authors: |
Dalmar, Ahmed; Singh, Maharaj; Ullah, Rafath; Heis, Zoe; Jan, M Fuad; Ammar, Khawaja A; Choudhuri, Indrajit; Sulemanjee, Nasir; Allaqaband, Suhail; Chua, Thomas; Sra, Jasbir; Tajik, A Jamil; Jahangir, A |
| Source: |
Aurora UW Cardiology Faculty |
| Publisher Information: |
SHARE @ Advocate Health - Midwest |
| Publication Year: |
2017 |
| Collection: |
Aurora Health Care Digital Repository |
| Subject Terms: |
Aurora UW Electrophysiology Faculty; Aurora UW Heart Failure Faculty; Cardiology; Diversity Equity and Inclusion |
| Description: |
Background: Weight loss after bariatric surgery in morbidly obese patients reduces adverse cardiovascular (CV) outcomes; but racial differences in the effectiveness of weight loss and its impact on CV outcomes are not defined. Purpose: To determine differences in laparoscopic adjustable gastric banding (LAGB)-induced weight loss and its impact on long-term CV events (myocardial infarction, heart failure [HF], atrial fibrillation [AF], stroke, and pulmonary embolism] in morbidly obese white and black patients. Method: Patients with morbid obesity (body mass index [BMI] ≥40 kg/m2 or 35 kg/m2 with obesity-related comorbidity) who underwent LAGB between 2001–2011 at a single institution with long-term follow-up were included. Differences in weight loss after LAGB in white and black patients and its impact on CV events were determined by Kaplan-Meier analysis, and predictors for CV outcomes were identified using Cox regression analysis. Results: Of 760 obese patients who underwent LAGB, 173 (23%) were black and 587 (77%) white. After 1:1 propensity matching for age, BMI, hypertension, dyslipidemia, and diabetes mellitus, 212 patients (106 in each group, with mean age 44±10 years, mean BMI 48±8kg/m2) were followed for CV events. Over a mean follow-up of 5.8±3.0 years, both groups had significant weight loss from baseline with a reduction in BMI of 21.5% (from 51 to 40 kg/m2) in the white patient group and 19.2% (from 48.2 to 39.0 kg/m2) in the black patient group, which was not significantly different between the groups (p=0.60). Despite similar reduction in BMI after LAGB, the cumulative CV events were significantly higher in the black patients than the white patients (log-rank p=0.03, Fig A), mainly due to a higher incidence of HF (7.5% vs 1.9%, p=0.05) and AF (6.6% vs 1.9%, p=0.05) in black patients (Fig B). Black race was an independent predictor of CV events [hazard ratio (HR): 2.60, 95% CI: 1.18–5.69, p View largeDownload slide Conclusion: Although no difference in weight loss and its maintenance after LAGB is ... |
| Document Type: |
text |
| Language: |
unknown |
| Relation: |
https://institutionalrepository.aah.org/cardiologyfaculty/57 |
| DOI: |
10.1093/eurheartj/ehx504.P4416 |
| Availability: |
https://institutionalrepository.aah.org/cardiologyfaculty/57; https://doi.org/10.1093/eurheartj/ehx504.P4416 |
| Accession Number: |
edsbas.17E943E5 |
| Database: |
BASE |