| Title: |
Abstract 4339213: Association of Chronic Kidney Disease with Incident Probable Dementia and Cognitive Impairment in the SPRINT trial |
| Authors: |
Samimisedeh, Parham; Kazibwe, Richard; Schaich, Christopher; Hughes, Timothy; Soliman, Elsayed |
| Source: |
Circulation ; volume 152, issue Suppl_3 ; ISSN 0009-7322 1524-4539 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2025 |
| Description: |
Background: Emerging evidence links chronic kidney disease (CKD) to an elevated risk of dementia and cognitive impairment, but the strength of this association in patients with hypertension remains uncertain. Objective: We examined the association of baseline CKD with incident probable dementia (PD), mild cognitive impairment (MCI), and a composite of both outcomes in patients with hypertension enrolled in the Systolic Blood Pressure Intervention Trial (SPRINT). Methods: SPRINT enrolled adults aged ≥50 years with hypertension but without diabetes or prior stroke. In this ad hoc analysis, participants with baseline pre-existing clinical dementia, prescribed dementia medications, or with missing eGFR or cognition data were excluded. Baseline CKD was defined as an estimated glomerular filtration rate (eGFR) |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1161/circ.152.suppl_3.4339213 |
| Availability: |
https://doi.org/10.1161/circ.152.suppl_3.4339213 |
| Accession Number: |
edsbas.17FC6D2B |
| Database: |
BASE |