| Title: |
68-Gallium DOTATATE scanning in symptomatic patients with negative anatomic imaging but suspected neuroendocrine tumor |
| Authors: |
Jasmine Shell; Xavier M Keutgen; Corina Millo; Naris Nilubol; Dhaval Patel; Samira Sadowski; Myriem Boufraqech; Lily Yang; Roxanne Merkel; Christine Atallah; Peter Herscovitch; Electron Kebebew |
| Source: |
International Journal of Endocrine Oncology, Vol 5, Iss 1 (2018) |
| Publisher Information: |
Future Medicine Ltd |
| Publication Year: |
2018 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
68-Gallium DOTATATE; biochemistry; carcinoid; neuroendocrine tumor; symptoms; Diseases of the endocrine glands. Clinical endocrinology; RC648-665; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; RC254-282 |
| Description: |
Aim: The study's aim was to determine the utility of 68-Gallium DOTATATE positron emission tomography (PET)-CT scanning in patients with carcinoid-like symptoms and negative anatomical imaging. Methods: Retrospective analysis of 22 of 196 patients with carcinoid-like symptoms and no evidence of primary neuroendocrine tumor (NET) based on anatomical imaging and endoscopy who underwent 68-Gallium DOTATATE PET-CT as part of a prospective clinical trial. Results: Of the biochemically positive patients (n = 11), 18% (n = 2) had additional evidence of NETs based on 68-Gallium DOTATATE PET-CT. Of the patients identified by 68-Gallium DOTATATE PET-CT, 50% (n = 1) had a treatment change and 100% showed symptom improvement. Of the biochemically negative patients (n = 11), 68-Gallium DOTATATE PET-CT identified NETs in 64% (n = 7). Change in management occurred in 71% patients, and 57% of patients showed symptom improvement. Conclusion: 68-Gallium DOTATATE PET-CT imaging is useful in detecting NETs in symptomatic patients with negative anatomical imaging and changes the treatments in these patients. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doaj.org/toc/2045-0869; https://doaj.org/toc/2045-0877; https://doaj.org/article/7c3463ae2e8e43d9a523eae573263494 |
| DOI: |
10.2217/ije-2017-0005 |
| Availability: |
https://doi.org/10.2217/ije-2017-0005; https://doaj.org/article/7c3463ae2e8e43d9a523eae573263494 |
| Accession Number: |
edsbas.18301714 |
| Database: |
BASE |