| Title: |
Incidence, Associated Abnormalities, and Outcomes of Dextrocardia: A Registry-based Study in Saudi Arabia |
| Authors: |
ALGhasab NS; Alshehri B; ALMesned S; Harbi H; ALAmeer R; ALShehri F; ALZeid A; ALZhrani M; ALMutiri GT; Al-Saud SA; Alobaid F; Alnajashi KS; Fogacci F; Cicero AFG; Kharabsheh SM |
| Contributors: |
Alghasab, N; Alshehri, B; Almesned, S; Harbi, H; Alameer, R; Alshehri, F; Alzeid, A; Alzhrani, M; Almutiri, Gt; Al-Saud, Sa; Alobaid, F; Alnajashi, K; Fogacci, F; Cicero, Arrigo Francesco Giuseppe; Kharabsheh, Sm |
| Publication Year: |
2025 |
| Collection: |
IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: |
Cardiac anomalie; Congenital cyanotic heart disease; Dextrocardia; Isolated dextrocardia; Situs ambiguou; Situs inversus |
| Description: |
Objective: Dextrocardia refers to the right-sided positioning of the heart during embryonic development and may occur in isolation or in association with visceral malposition or other malformations. However, few studies have investigated this condition. This study aimed to determine the incidence of cardiac and non-cardiac malformations, as well as to analyze long-term follow-up and survival outcomes in patients with dextrocardia. Methods: This was a retrospective chart review of dextrocardia cases at King Faisal Specialist Hospital & Research Centre in Riyadh, Saudi Arabia from April 22, 1975, to December 31, 2016. A total of 259,246 transthoracic echocardiograms from that period were reviewed, and 357 patients were included in the analysis. Results: The incidence of dextrocardia was approximately 1 in 28,571 pregnancies (0.35 per 10,000 pregnancies). Most patients with dextrocardia were between 2 and 18 years old (n = 252, 70.6 %). The most common type was isolated dextrocardia (situs solitus), followed by situs inversus totalis, and situs ambiguous. The most common congenital cyanotic heart diseases were double outlet right ventricle (n = 55, 15.5 %) and pulmonary atresia (n = 35, 9.8 %). The most common acyanotic congenital abnormalities were ventricular (n = 152, 42.7 %) and atrial (n = 121, 34.2 %) septal defects. Overall survival in the study population was approximately 83 %. Survival rates varied by situs type, with the highest rates observed in patients with situs inversus (96 %), followed by those with situs solitus (91 %), and situs ambiguous (55 %). Moderate to severe pulmonary hypertension was significantly associated with a reduction in overall survival. The most common non-cardiac anomalies observed were gastrointestinal and urogenital abnormalities. Conclusion: This study describes the largest regional cohort of patients with dextrocardia, providing important insights into dextrocardia and outcomes of different intracardiac defects in our community. Our findings confirm that complex ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40661864; info:eu-repo/semantics/altIdentifier/wos/WOS:001538729700001; volume:37; issue:3; firstpage:1; lastpage:12; numberofpages:12; journal:JOURNAL OF THE SAUDI HEART ASSOCIATION; https://hdl.handle.net/11585/1037070 |
| DOI: |
10.37616/2212-5043.1438 |
| Availability: |
https://hdl.handle.net/11585/1037070; https://doi.org/10.37616/2212-5043.1438; https://www.j-saudi-heart.com/jsha/vol37/iss3/6/ |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND) ; license uri:iris.PUB17 |
| Accession Number: |
edsbas.1847E854 |
| Database: |
BASE |