| Title: |
National Unified Renal Translational Research Enterprise: Idiopathic Nephrotic Syndrome (NURTuRE-INS) study |
| Authors: |
Colby, Elizabeth; Hayward, Samantha; Benavente, Melissa; Robertson, Fiona; Bierzynska, Agnieszka; Osborne, Amy; Parmesar, Kevon; Afzal, Maryam; Chapman, Tracey; Ullah, Fatima; Davies, Elaine; Nation, Michael; Cook, Wendy; Johnson, Tim; Andag, Uwe; Radresa, Olivier; Skroblin, Philipp; Bayerlova, Michaela; Unwin, Robert; Vuilleumier, Nicolas; Banks, Rosamonde E; Braddon, Fiona; Koziell, Ania; Taal, Maarten W; Welsh, Gavin I; Saleem, Moin A |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2024 |
| Collection: |
University of Nottingham: Repository@Nottingham |
| Subject Terms: |
biobank; focal segmental glomerulosclerosis; idiopathic nephrotic syndrome; minimal change disease |
| Description: |
BackgroundIdiopathic Nephrotic Syndrome (INS) is a heterogenous disease and current classification is based on observational responses to therapies or kidney histology. The National Unified Renal Translational Research Enterprise (NURTuRE)-INS cohort aims to facilitate novel ways of stratifying INS patients to improve disease understanding, therapeutics, and design of clinical trials.MethodsNURTuRE-INS is a prospective cohort study of children and adults with INS with a linked biorepository. All recruits had at least one sampling visit collecting serum, plasma, urine and blood for RNA and DNA extraction, frozen within 2 hours of collection. Clinical histology slides and biopsy tissue blocks were also collected.ResultsIn total, 739 participants were recruited from 23 centres to NURTuRE-INS, half of whom were diagnosed in childhood (n = 365, 49%). The majority were white (n = 525, 71%) and the median age at recruitment was 32 (interquartile range 12-54). Steroid-sensitive nephrotic syndrome (SSNS) was the most common clinical diagnosis (n = 518, 70%). Of patients diagnosed in childhood who underwent a kidney biopsy - for SSNS (n=103), 76 demonstrated minimal change disease (MCD); whereas for steroid-resistant nephrotic syndrome (n=80), 21 had MCD. Almost all patients diagnosed in adulthood had a kidney biopsy (n = 352, 94%); 187 MCD and 162 focal segmental glomerulosclerosis.ConclusionsNURTuRE-INS is a prospective cohort study with high-quality biosamples and longitudinal data that will assist research into the mechanistic stratification of INS. Samples and data will be available through a Strategic Access and Oversight Committee. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://nottingham-repository.worktribe.com/output/32457888; Clinical Kidney Journal; Volume 17; Issue 8 |
| DOI: |
10.1093/ckj/sfae096 |
| Availability: |
https://doi.org/10.1093/ckj/sfae096; https://nottingham-repository.worktribe.com/file/32457888/1/Original%20Article%20Format%20-%20NURTuRE-INS%20-%20CKJ%20Accpted; https://nottingham-repository.worktribe.com/output/32457888 |
| Rights: |
openAccess ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.1866C2DE |
| Database: |
BASE |