| Title: |
Rational and design of EACVI-MMVD study: an international registry on multimodality imaging for mixed and multiple valvular heart disease |
| Authors: |
Unger, Alexandre; Mandoli, Giulia Elena; Neglia, Danilo; Romero Dorta, Elena; Kagiyama, Nobuyuki; Borodzicz-Jazdzyk, Sonia; Velegraki, Eirini; Coisne, Augustin; Uygur, Begüm; Afana, Andreea; Florence, Jeremy; Bohbot, Yohann; Donal, Erwan; Clavel, Marie-Annick; Pibarot, Philippe; Unger, Philippe; Manka, Robert; Nijveldt, Robin; Gimelli, Alessia; Gerber, Bernhard; Dweck, Marc; Muraru, Denisa; Pontone, Gianluca; Ajmone Marsan, Nina; Timoteo, Ana Teresa; Toupin, Solenn; Pereira, Christine; Cosyns, Bernard; Vicaut, Eric; Delgado, Victoria; Petersen, Steffen; Pezel, Théo |
| Contributors: |
A. Unger; G.E. Mandoli; D. Neglia; E. Romero Dorta; N. Kagiyama; S. Borodzicz-Jazdzyk; E. Velegraki; A. Coisne; B. Uygur; A. Afana; J. Florence; Y. Bohbot; E. Donal; M. Clavel; P. Pibarot; P. Unger; R. Manka; R. Nijveldt; A. Gimelli; B. Gerber; M. Dweck; D. Muraru; G. Pontone; N. Ajmone Marsan; A.T. Timoteo; S. Toupin; C. Pereira; B. Cosyn; E. Vicaut; V. Delgado; S. Petersen; T. Pezel |
| Publisher Information: |
Oxford University Press : European Association of Cardiovascular Imaging (EACVI) : European Society of Cardiology (ESC) |
| Publication Year: |
2026 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
European Association of Cardiovascular Imaging (EACVI); core laboratory; multimodality imaging; multiple and mixed valvular heart disease; prognosi; valvular heart disease; Settore MEDS-07/B - Malattie dell'apparato cardiovascolare |
| Description: |
Aims: Multiple and mixed valvular heart disease (MMVD) are frequent situations in clinical practice. Despite a high prevalence, comprehensive insights into their clinical presentation, management strategies, impact of multimodality imaging, and outcomes are not well established, due to a lack of dedicated studies. Methods and results: The 'EACVI-MMVD Study' will be a large prospective, multicentre, observational cohort study led by the Heart Imagers of Tomorrow of the European Association of Cardiovascular Imaging (EACVI). It will assess the proportion, management, and prognosis of MMVD over a 1-year period of follow-up. All consecutive patients diagnosed with MMVD using transthoracic echocardiography will be recruited over a 6-month recruitment period in 88 centres from 24 different countries. Baseline evaluation will be determined by physicians and encompass the whole spectrum of multimodality imaging including transthoracic and transoesophageal echocardiography, stress echocardiography, computed tomography, and cardiovascular magnetic resonance. Centres will have the opportunity to send cardiovascular imaging data for core laboratory analysis and to extend recruitment throughout a 5-year follow-up period. Conclusion: The EACVI-MMVD study will be the largest international multicentre study evaluating the prevalence of MMVD in clinical routine and determining the impact of multimodality cardiovascular imaging in MMVD patients.Clinical Trial Registration: NCT06235385 URL: https://classic.clinicaltrials.gov/ct2/show/NCT06235385. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/41635678; volume:4; issue:1; firstpage:1; lastpage:8; numberofpages:8; journal:EUROPEAN HEART JOURNAL. IMAGING METHODS AND PRACTICE; https://hdl.handle.net/2434/1221317 |
| DOI: |
10.1093/ehjimp/qyaf156 |
| Availability: |
https://hdl.handle.net/2434/1221317; https://doi.org/10.1093/ehjimp/qyaf156 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.187D492 |
| Database: |
BASE |