| Title: |
Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study. |
| Authors: |
Schreiber, Peter W; Bischoff-Ferrari, Heike A; Boggian, Katia; van Delden, Christian; Enriquez, Natalia; Fehr, Thomas; Garzoni, Christian; Hirsch, Hans H; Hirzel, Cédric; Manuel, Oriol; Meylan, Pascal; Saleh, Lanja; Weisser, Maja; Mueller, Nicolas J |
| Source: |
Schreiber, Peter W; Bischoff-Ferrari, Heike A; Boggian, Katia; van Delden, Christian; Enriquez, Natalia; Fehr, Thomas; Garzoni, Christian; Hirsch, Hans H; Hirzel, Cédric; Manuel, Oriol; Meylan, Pascal; Saleh, Lanja; Weisser, Maja; Mueller, Nicolas J (2019). Vitamin D status and risk of infections after liver transplantation in the Swiss Transplant Cohort Study. Transplant international, 32(1), pp. 49-58. Wiley-Blackwell 10.1111/tri.13328 |
| Publisher Information: |
Wiley-Blackwell |
| Publication Year: |
2019 |
| Collection: |
BORIS (Bern Open Repository and Information System, University of Bern) |
| Subject Terms: |
610 Medicine & health |
| Description: |
MAIN PROBLEM Increasing evidence indicates a role of vitamin D in the immune system affecting response to infections. We aimed to characterize the role of vitamin D status, i.e. deficiency (25-OH vitamin D [25-OHD] < 50nmol/l) and no deficiency (25-OHD ≥ 50nmol/l) in incident infections after liver transplantation. METHODS In 135 liver transplant recipients blood samples drawn at time of liver transplantation and 6 months afterwards were used to determine 25-OHD levels. Incident infections episodes were prospectively collected within the STCS database. Poisson regression was applied to address associations between vitamin D status and incident infections. RESULTS Vitamin D deficiency was common at time of transplantation and 6 months afterwards without a significant change in median 25-OHD levels. In univariable analyses vitamin D deficiency was a risk factor for incident infections in the first 6 months post-transplant (IRR 1.52, 95% CI 1.08-2.15, P=0.018) and for bacterial infections occurring after 6 up to 30 months post-transplant (IRR 2.29, 95% CI 1.06-4.94, P=0.034). These associations were not detectable in multivariable analysis with adjustment for multiple confounders. CONCLUSIONS Efforts to optimize vitamin D supplementation in liver transplant recipients are needed. Our data question the role of vitamin D deficiency in incident infections. This article is protected by copyright. All rights reserved. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://boris.unibe.ch/119433/ |
| Availability: |
https://boris.unibe.ch/119433/1/Schreiber_et_al-2018-Transplant_International.pdf; https://boris.unibe.ch/119433/ |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.18935E23 |
| Database: |
BASE |