| Title: |
Multi-Gene Testing Overview with a Clinical Perspective in Metastatic Triple-Negative Breast Cancer |
| Authors: |
Martina Dameri; Lorenzo Ferrando; Gabriella Cirmena; Claudio Vernieri; Giancarlo Pruneri; Alberto Ballestrero; Gabriele Zoppoli |
| Source: |
International Journal of Molecular Sciences, Vol 22, Iss 7154, p 7154 (2021) |
| Publisher Information: |
MDPI AG |
| Publication Year: |
2021 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
next-generation sequencing; multi-gene testing; gene panels; breast cancer; metastatic triple-negative breast cancer; tumor mutational burden; Biology (General); QH301-705.5; Chemistry; QD1-999 |
| Description: |
Next-generation sequencing (NGS) is the technology of choice for the routine screening of tumor samples in clinical practice. In this setting, the targeted sequencing of a restricted number of clinically relevant genes represents the most practical option when looking for genetic variants associated with cancer, as well as for the choice of targeted treatments. In this review, we analyze available NGS platforms and clinical applications of multi-gene testing in breast cancer, with a focus on metastatic triple-negative breast cancer (mTNBC). We make an overview of the clinical utility of multi-gene testing in mTNBC, and then, as immunotherapy is emerging as a possible targeted therapy for mTNBC, we also briefly report on the results of the latest clinical trials involving immune checkpoint inhibitors (ICIs) and TNBC, where NGS could play a role for the potential predictive utility of homologous recombination repair deficiency (HRD) and tumor mutational burden (TMB). |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.mdpi.com/1422-0067/22/13/7154; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/d52e407330724105bcb578d52349ab3a |
| DOI: |
10.3390/ijms22137154 |
| Availability: |
https://doi.org/10.3390/ijms22137154; https://doaj.org/article/d52e407330724105bcb578d52349ab3a |
| Accession Number: |
edsbas.1895F9C5 |
| Database: |
BASE |