| Title: |
Effects of Microtubule Modulators on HIV-1 Infection of Transformed and Resting CD4 T Cells |
| Authors: |
Yoder, Alyson; Guo, Jia; Yu, Dongyang; Cui, Zongqiang; Zhang, Xian-En; Wu, Yuntao |
| Source: |
Journal of Virology ; volume 85, issue 6, page 3020-3024 ; ISSN 0022-538X 1098-5514 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2011 |
| Description: |
Previous studies have observed fluorescently labeled HIV particles tracking along microtubule networks for nuclear localization. To provide direct evidence for the involvement of microtubules in early steps of HIV infection of human CD4 T cells, we used multiple microtubule modulators such as paclitaxel (originally called taxol; 1 μM), vinblastine (1 and 10 μM), colchicine (10 and 100 μM), and nocodazole (10 and 100 μM) to disturb microtubule networks in transformed and resting CD4 T cells. Although these drugs disrupted microtubule integrity, almost no inhibition of HIV-1 infection was observed. Our results do not appear to support an essential role for microtubules in the initiation of HIV infection of CD4 T cells. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/jvi.02462-10 |
| DOI: |
10.1128/JVI.02462-10 |
| Availability: |
https://doi.org/10.1128/jvi.02462-10; https://journals.asm.org/doi/pdf/10.1128/JVI.02462-10 |
| Rights: |
https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.18989DBA |
| Database: |
BASE |