| Title: |
The Nose as a Route for Therapy: Part 1. Pharmacotherapy |
| Authors: |
Cingi, C; Bayar Muluk, N; Mitsias, DI; Papadopoulos, NG; Klimek, L; Laulajainen-Hongisto, A; Hytönen, M; Toppila-Salmi, SK; Scadding, GK |
| Source: |
Frontiers in Allergy , 2 , Article 638136. (2021) |
| Publisher Information: |
Frontiers Media SA |
| Publication Year: |
2021 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
allergic rhinitis; chronic rhinosinusitis; drug delivery; intranasal route; lysine aspirin; mucociliary clearance; nasal epithelium; saline douche |
| Description: |
This article reviews nasal structure and function in the light of intranasal pharmacotherapy. The nose provides an accessible, fast route for local treatment of nose and sinus diseases, with lower doses than are necessary systemically and few adverse effects. It can also be used for other medications as it has sufficient surface area protected from local damage by mucociliary clearance, absence of digestive enzymes, responsive blood flow, and provides a rapid route to the central nervous system. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10205820/1/The%20Nose%20as%20a%20Route%20for%20Therapy%20Part%201.%20Pharmacotherapy.pdf; https://discovery.ucl.ac.uk/id/eprint/10205820/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10205820/1/The%20Nose%20as%20a%20Route%20for%20Therapy%20Part%201.%20Pharmacotherapy.pdf; https://discovery.ucl.ac.uk/id/eprint/10205820/ |
| Rights: |
open |
| Accession Number: |
edsbas.18EED5A8 |
| Database: |
BASE |