| Title: |
Biomarker-confirmed suboptimal adherence to isoniazid preventive therapy among children with HIV in western Kenya |
| Authors: |
Onyango, Dickens Otieno; van der Sande, Marianne A.B.; Yuen, Courtney M.; Were, Joyce; Mecha, Jerphason; Njagi, Lilian N.; Panpradist, Nuttada; Matemo, Daniel; Leon, Daniel; Lutz, Barry; Kinuthia, John; John-Stewart, Grace; Lacourse, Sylvia M. |
| Source: |
AIDS ; volume 38, issue 1, page 39-47 ; ISSN 0269-9370 1473-5571 |
| Publisher Information: |
Ovid Technologies (Wolters Kluwer Health) |
| Publication Year: |
2023 |
| Description: |
Objectives: The aim of this study was to assess the level and correlates of biomarker-confirmed adherence to isoniazid (INH) preventive therapy (IPT) among children with HIV (CLHIV). Design: This prospective cohort study assessed adherence among CLHIV on IPT in public sector HIV clinics from 2019 through 2020. Methods: Adherence was assessed by pill counts or caregiver or self-reports, and urine biomarkers (in-house dipstick and Isoscreen). Both urine biomarker tests detect INH metabolites within 48 h of ingestion. Consistent adherence was defined as having positive results on either biomarker at all visits. Correlates of biomarker-confirmed nonadherence at each visit were evaluated using generalized estimating equations. The in-house dipstick was validated using Isoscreen as the reference. Results: Among 97 CLHIV on IPT with adherence assessments, median age was 10 years (IQR 7–13). All were on ART at IPT initiation (median duration 46 months [IQR 4–89]); 81% were virally suppressed ( |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1097/qad.0000000000003719 |
| DOI: |
10.1097/QAD.0000000000003719 |
| Availability: |
https://doi.org/10.1097/qad.0000000000003719; https://journals.lww.com/10.1097/QAD.0000000000003719 |
| Accession Number: |
edsbas.18F8505 |
| Database: |
BASE |