| Title: |
Bisphenol S fetal exposure in ewes exhibiting contrasted metabolic status impaired the ovarian follicular development of fetuses and lambs |
| Authors: |
Téteau, Ophélie; Lebachelier de la Riviere, Marie-Emilie; Adriaensen, Hans; Lasserre, Olivier; Lacroix, Marlène; Corset, Laetitia; Jarrier-Gaillard, Peggy; Papillier, Pascal; Desmarchais, Alice; Freret, Sandrine; Maillard, Virginie; Gayrard, Véronique; Picard-Hagen, Nicole; Elis, Sébastien |
| Contributors: |
Physiologie de la reproduction et des comportements Nouzilly (PRC); Université de Tours (UT); NEOLAiA European University = Université Européenne NEOLAÏA (NEOLAiA)-NEOLAiA European University = Université Européenne NEOLAÏA (NEOLAiA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Plate-forme Phénotypage par imagerie in/ex vivo de l'Animal à la Molécule (Plate-forme PIXANIM); Centre Hospitalier Régional Universitaire de Tours (CHRU Bretonneau)-Physiologie de la reproduction et des comportements Nouzilly (PRC); NEOLAiA European University = Université Européenne NEOLAÏA (NEOLAiA)-NEOLAiA European University = Université Européenne NEOLAÏA (NEOLAiA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Tours (UT); Unité Expérimentale de Physiologie Animale de l‘Orfrasiére (UE PAO); Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Innovations Thérapeutiques et Résistances (InTheRes); École nationale vétérinaire de Toulouse (ENVT); Institut National Polytechnique (Toulouse) (Toulouse INP); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National Polytechnique (Toulouse) (Toulouse INP); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Institut Français du Cheval et de l'Equitation Saumur (IFCE)-Université de Tours (UT); ToxAlim (ToxAlim); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université de Toulouse (EPE UT); Communauté d'universités et établissements de Toulouse (Comue de Toulouse)-Ecole d'Ingénieurs de Purpan (EI Purpan); Communauté d'universités et établissements de Toulouse (Comue de Toulouse); ANR-18-CE34-0011,MAMBO,Impact du métabolisme sur les effets ovariens du bisphenol S(2018) |
| Source: |
ISSN: 1757-2215 ; Journal of Ovarian Research ; https://hal.inrae.fr/hal-05675048 ; Journal of Ovarian Research, 2026, ⟨10.1186/s13048-026-02182-y⟩. |
| Publisher Information: |
CCSD; BioMed Central |
| Publication Year: |
2026 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
[SDV]Life Sciences [q-bio]; [SDE]Environmental Sciences |
| Description: |
International audience ; Abstract The size of the ovarian reserve, defined by the pool of primordial follicles, is established during fetal life in women and sheep. The prenatal period is a critical window of sensitivity, especially for ovarian development. Maternal metabolic status and nutrition during gestation can influence fetal programming, and affect the establishment of ovarian reserve. In addition, the developing fetus is particularly sensitive to endocrine disruptors. Bisphenol A (BPA), a plasticizer widely used in food packaging, has deleterious effects on fetal folliculogenesis. BPA has been banned from the food industry and has been replaced mainly by bisphenol S (BPS), whose effects on ovarian development remain poorly characterized. The objective of this study was to determine the effects of in utero exposure to BPS (50 µg/kg/day) on ovarian development in female fetuses, and lambs, using histology and/or magnetic resonance imaging (MRI). In addition, pregnant ewes exhibited contrasted metabolic status (lean versus fat), allowing assessment of the interaction between maternal nutrition and BPS exposure. This study was divided into two experiments. In the first, pregnant ewes received daily subcutaneous injection of BPS for 3 months, and fetal ovarian development was analyzed at 130 days of gestation. In the second, pregnant ewes were exposed daily to BPS through food for 3 months and female lambs were then monitored up to 4-month-old (pre-puberty). In offspring of fat mothers, the body weight of the fetuses increased but this increase was not observed anymore in lambs. Plasma anti-Mullerian hormone (AMH) concentrations decreased in 1-month-old lambs and the antral follicle number increased in both fetuses and 4-month-old lambs from well-fed mothers. In addition, a significant interaction between maternal metabolic status and gestational BPS exposure was reported for the numbers of primordial, intermediate and total follicles of fetuses, with a similar trend for pre-antral follicles. Such ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1186/s13048-026-02182-y |
| Availability: |
https://hal.inrae.fr/hal-05675048; https://doi.org/10.1186/s13048-026-02182-y |
| Accession Number: |
edsbas.18FA5FF2 |
| Database: |
BASE |