| Title: |
European Association of Urology Guidelines on Muscle-invasive and Metastatic Bladder Cancer: Summary of the 2025 Guidelines |
| Authors: |
van der Heijden, Antoine G.; Bruins, Harman Max; Carrion, Albert; Cathomas, Richard; Compérat, Eva; Dimitropoulos, Konstantinos; Efstathiou, Jason A.; Fietkau, Rainer; Kailavasan, Mithun; Lorch, Anja; Martini, Alberto; Mertens, Laura S.; Meijer, Richard P.; Mariappan, Param; Milowsky, Matthew I.; Neuzillet, Yann; Panebianco, Valeria; Sæbjørnsen, Sæbjørn; Smith, Emma J.; Thalmann, George N.; Rink, Michael |
| Contributors: |
Van Der Heijden, Antoine G.; Bruins, Harman Max; Carrion, Albert; Cathomas, Richard; Compérat, Eva; Dimitropoulos, Konstantino; Efstathiou, Jason A.; Fietkau, Rainer; Kailavasan, Mithun; Lorch, Anja; Martini, Alberto; Mertens, Laura S.; Meijer, Richard P.; Mariappan, Param; Milowsky, Matthew I.; Neuzillet, Yann; Panebianco, Valeria; Sæbjørnsen, Sæbjørn; Smith, Emma J.; Thalmann, George N.; Rink, Michael |
| Publisher Information: |
Elsevier B.V. |
| Publication Year: |
2025 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
Bladder cancer; Classification; Cystoscopy; Diagnosi; Follow-up; Guideline; Marker prognosi; Radical cystectomy; Transurethral resection; Urothelial carcinoma |
| Description: |
Background and objective: This publication represents a summary of the updated 2025 European Association of Urology (EAU) guidelines for muscle-invasive and metastatic bladder cancer (MMIBC). The aim is to provide practical recommendations on the clinical management of MMIBC with a focus on diagnosis, treatment, and follow-up. Methods: For the 2025 guidelines, new and relevant evidence was identified, collated, and appraised via a structured assessment of the literature. Databases searched included Medline, EMBASE, and the Cochrane Libraries. Recommendations within the guidelines were developed by the panel to prioritise clinically important care decisions. The strength of each recommendation was determined according to a balance between desirable and undesirable consequences of alternative management strategies, the quality of the evidence (including the certainty of estimates), and the nature and variability of patient values and preferences. Key findings and limitations: The key recommendations emphasise the importance of thorough diagnosis, treatment, and follow-up for patients with MMIBC. The guidelines stress the importance of a multidisciplinary approach to the treatment of MMIBC patients and the importance of shared decision-making with patients. The key changes in the 2025 muscle-invasive bladder cancer (MIBC) guidelines include the following: a new recommendation for the use of susceptible FGFR3 alterations to select patients with unresectable or metastatic urothelial carcinoma for treatment with erdafitinib; significant adaption and update of the recommendations for pre- and postoperative radiotherapy and sexual organ–preserving techniques in women; new recommendation related to radical cystectomy and extent of lymph node dissection based on the results of the SWOG trial; recommendation related to hospital volume; new recommendations for salvage cystectomy after trimodality therapy and for the management of all patients who are candidates for trimodality bladder-preserving treatment in a ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40118736; info:eu-repo/semantics/altIdentifier/wos/WOS:001472688900001; volume:87; issue:5; firstpage:582; lastpage:600; numberofpages:19; journal:EUROPEAN UROLOGY; https://hdl.handle.net/11573/1738668 |
| DOI: |
10.1016/j.eururo.2025.02.019 |
| Availability: |
https://hdl.handle.net/11573/1738668; https://doi.org/10.1016/j.eururo.2025.02.019 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.191F2A1 |
| Database: |
BASE |