| Title: |
Insulin dysregulation in horses : population prevalence, seasonal variation, and the effects of alpha-2-adrenoceptor activation |
| Authors: |
Box, Justin |
| Contributors: |
Helsingin yliopisto, eläinlääketieteellinen tiedekunta; University of Helsinki, Faculty of Veterinary Sciences, Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine; Helsingfors universitet, veterinärmedicinska fakulteten; Bröjer, Johan; Karikoski, Ninja; Raekallio, Marja |
| Publisher Information: |
Helsingin yliopisto; Helsingfors universitet; University of Helsinki |
| Publication Year: |
2023 |
| Collection: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| Subject Terms: |
veterinary medicine; equine internal medicine; Doktorandprogrammet i klinisk veterinärmedicin; Kliinisen eläinlääketieteen tohtoriohjelma; Doctoral Programme in Clinical Veterinary Medicine; 413 Veterinary science; 413 Eläinlääketiede; 413 Veterinärvetenskap |
| Description: |
Insulin dysregulation (ID) and obesity predispose horses to the painful condition laminitis. Understanding which management practices and phenotypic markers of obesity are associated with ID may help improve animal welfare. Furthermore, the prevalence of ID in horses has been studied in other horse populations but not in Finnhorses. The oral sugar test (OST) is one method for determining ID status in horses, but the potential for variation in OST results throughout a year have not been determined. Sedatives in the α2-adrenoceptor agonist class can alter blood glucose (BG) as well as serum insulin concentrations in the horse. Vatinoxan (an α2-adrenoceptor antagonist) poorly penetrates the blood-brain-barrier and can alleviate the negative peripheral effects of α2-agonists. However, the effect of a vatinoxan/detomidine combination on ID horses has not been studied. This thesis aimed to determine the frequency of ID in a population of Finnhorses in southern Finland and compare management factors and phenotypic markers of obesity between ID and non-ID horses. Furthermore, it aimed to detect whether serum insulin concentration varied throughout a year and evaluate risk factors associated with ID. Finally, this thesis aimed to determine the effects detomidine and vatinoxan had on insulin and BG in ID and non-ID horses. For study I, 128 Finnhorses were evaluated. Phenotypic markers of obesity and weight were recorded, and an OST (corn syrup 0.45 ml/kg) was performed after an overnight fast. Horses were considered ID if insulin concentration was ≥ 33 μIU/mL at baseline, ≥ 66 μIU/mL at 60 or 90, minutes or in some combination (Immulite 2000 XPi). Using mixed effects logistic regression modeling, the association between ID, certain management factors, and phenotypic markers were evaluated. Only obesity was significantly associated with ID. Sixteen percent of the horses were classified as ID, while 60% were considered overweight or obese. For study II, an OST was performed on 29 Finnhorses every other month for a total of ... |
| Document Type: |
doctoral or postdoctoral thesis |
| File Description: |
application/pdf |
| Language: |
English |
| ISBN: |
978-951-51-9228-8; 951-51-9228-5 |
| Relation: |
https://hdl.handle.net/10138/357195 |
| Availability: |
https://hdl.handle.net/10138/357195 |
| Rights: |
Julkaisu on tekijänoikeussäännösten alainen. Teosta voi lukea ja tulostaa henkilökohtaista käyttöä varten. Käyttö kaupallisiin tarkoituksiin on kielletty. ; This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. ; Publikationen är skyddad av upphovsrätten. Den får läsas och skrivas ut för personligt bruk. Användning i kommersiellt syfte är förbjuden. |
| Accession Number: |
edsbas.19214D3B |
| Database: |
BASE |