| Title: |
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors |
| Authors: |
Young, Matthew D.; Mitchell, Thomas J.; Vieira Braga, Felipe A.; Tran, Maxine G. B.; Stewart, Benjamin J.; Ferdinand, John R.; Collord, Grace; Botting, Rachel A.; Popescu, Dorin-Mirel; Loudon, Kevin W.; Vento-Tormo, Roser; Stephenson, Emily; Cagan, Alex; Farndon, Sarah J.; Del Castillo Velasco-Herrera, Martin; Guzzo, Charlotte; Richoz, Nathan; Mamanova, Lira; Aho, Tevita; Armitage, James N.; Riddick, Antony C. P.; Mushtaq, Imran; Farrell, Stephen; Rampling, Dyanne; Nicholson, James; Filby, Andrew; Burge, Johanna; Lisgo, Steven; Maxwell, Patrick H.; Lindsay, Susan; Warren, Anne Y.; Stewart, Grant D.; Sebire, Neil; Coleman, Nicholas; Haniffa, Muzlifah; Teichmann, Sarah A.; Clatworthy, Menna; Behjati, Sam |
| Contributors: |
Human Frontier Science Program; Wellcome Trust; Cancer Research UK; Cambridge Biomedical Research Campus; Kidney Cancer UK; Facing up 2 Kidney Cancer; St Baldrick’s Foundation; Lister Institute of Preventive Medicine; NIHR and Newcastle-Biomedical Research Centre; Arthritis Research UK; EMBO |
| Source: |
Science ; volume 361, issue 6402, page 594-599 ; ISSN 0036-8075 1095-9203 |
| Publisher Information: |
American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2018 |
| Description: |
Pediatric and adult kidney tumors differ Understanding tumor origins and the similarities and differences between organ-specific cancers is important for determining treatment options. Young et al. generated more than 72,000 single-cell transcriptomes from healthy and cancerous human kidneys. From these data, they determined that Wilms tumor, a pediatric kidney cancer, originates from aberrant fetal cells, whereas adult kidney cancers are likely derived from a specific subtype of proximal convoluted tubular cell. Science , this issue p. 594 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1126/science.aat1699 |
| Availability: |
https://doi.org/10.1126/science.aat1699; https://syndication.highwire.org/content/doi/10.1126/science.aat1699; https://www.science.org/doi/pdf/10.1126/science.aat1699 |
| Accession Number: |
edsbas.19299C0 |
| Database: |
BASE |