| Title: |
Fibroblast‐like synoviocytes preferentially induce terminal differentiation of IgD + memory B cells instead of naïve B cells |
| Authors: |
Bleck, Dennis; Loacker‐Schöch, Klara; Classen, Tim; Jose, Joachim; Schneider, Matthias; Pongratz, Georg |
| Source: |
Immunology ; volume 173, issue 3, page 520-535 ; ISSN 0019-2805 1365-2567 |
| Publisher Information: |
Wiley |
| Publication Year: |
2024 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Rheumatoid arthritis (RA) is a systemic autoimmune disease driven by highly active autoantibody‐producing B cells. Activation of B cells is maintained within ectopic germinal centres found in affected joints. Fibroblast‐like synoviocytes (FLS) present in inflamed joints support B‐cell survival, activation, and differentiation. CD27+ memory B cells and naive B cells show very different responses to activation, particularly by CD40 ligand (CD40L). We show that FLS‐dependent activation of human B cells is dependent on interleukin‐6 (IL‐6) and CD40L. FLS have been shown to activate both naive and memory B cells. Whether the activating potential of FLS is different for naive and memory B cells has not been investigated. Our results suggest that FLS‐induced activation of B cells is dependent on IL‐6 and CD40L. While FLS are able to induce plasma cell differentiation, isotype switching, and antibody production in memory B cells, the ability of FLS to activate naive B cells is significantly lower. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/imm.13840 |
| Availability: |
https://doi.org/10.1111/imm.13840; https://onlinelibrary.wiley.com/doi/pdf/10.1111/imm.13840 |
| Rights: |
http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.192B2492 |
| Database: |
BASE |