| Title: |
Promoting HIV indicator condition-guided testing in hospital settings (PROTEST 2.0): study protocol for a multicentre interventional study |
| Authors: |
Bogers, SJ; Schim van der Loeff, MF; Davidovich, U; Boyd, A; Van der Valk, M; Brinkman, K; De Bree, GJ; Reiss, P; Van Bergen, JEAM; Geerlings, SE; HIV Transmission Elimination AMsterdam (H-TEAM) Consortium |
| Contributors: |
Stichting Aidsfonds |
| Publisher Information: |
BioMed Central |
| Publication Year: |
2021 |
| Collection: |
Imperial College London: Spiral |
| Subject Terms: |
HIV testing; Healthcare quality improvement; Implementation; Indicator condition; Multifaceted intervention; HIV Transmission Elimination AMsterdam (H-TEAM) Consortium; Microbiology; 0605 Microbiology; 1103 Clinical Sciences; 1108 Medical Microbiology |
| Subject Geographic: |
England |
| Description: |
BACKGROUND: Late presentation remains a key barrier towards controlling the HIV epidemic. Indicator conditions (ICs) are those that are AIDS-defining, associated with a prevalence of undiagnosed HIV > 0.1%, or whose clinical management would be impeded if an HIV infection were undiagnosed. IC-guided HIV testing is an effective strategy in identifying undiagnosed HIV, but opportunities for earlier HIV diagnosis through IC-guided testing are being missed. We present a protocol for an interventional study to improve awareness of IC-guided testing and increase HIV testing in patients presenting with ICs in a hospital setting. METHODS: We designed a multicentre interventional study to be implemented at five hospitals in the region of Amsterdam, the Netherlands. Seven ICs were selected for which HIV test ratios (proportion of patients with an IC tested for HIV) will be measured: tuberculosis, cervical/vulvar cancer or high-grade cervical/vulvar dysplasia, malignant lymphoma, hepatitis B and C, and peripheral neuropathy. Prior to the intervention, a baseline assessment of HIV test ratios across ICs will be performed in eligible patients (IC diagnosed January 2015 through May 2020, ≥18 years, not known HIV positive) and an assessment of barriers and facilitators for HIV testing amongst relevant specialties will be conducted using qualitative (interviews) and quantitative methods (questionnaires). The intervention phase will consist of an educational intervention, including presentation of baseline results as competitive graphical audit and feedback combined with discussion on implementation and opportunities for improvement. The effect of the intervention will be assessed by comparing HIV test ratios of the pre-intervention and post-intervention periods. The primary endpoint is the HIV test ratio within ±3 months of IC diagnosis. Secondary endpoints are the HIV test ratio within ±6 months of diagnosis, ratio ever tested for HIV, HIV positivity percentage, proportion of late presenters and proportion with known HIV ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
BMC Infectious Diseases; http://hdl.handle.net/10044/1/89925; TBC |
| DOI: |
10.1186/s12879-021-06183-8 |
| Availability: |
http://hdl.handle.net/10044/1/89925; https://doi.org/10.1186/s12879-021-06183-8 |
| Rights: |
© The Author(s) 2021. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.1965EFBF |
| Database: |
BASE |