| Title: |
The TALAPRO-3 study design: a plain language summary |
| Authors: |
Saad, Fred; Matsubara, Nobuaki; Agarwal, Neeraj; Azad, Arun; Shore, Neal; Mateo, Joaquin |
| Contributors: |
Institut Català de la Salut; Agarwal N Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT, USA. Saad F University of Montréal Cancer Center, Montréal, Canada. Azad AA Peter MacCallum Cancer Centre, Melbourne, Australia. Mateo J Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Matsubara N National Cancer Center Hospital East, Chiba, Japan. Shore ND Carolina Urologic Research Center, Myrtle Beach, SC, USA; Vall d'Hebron Barcelona Hospital Campus |
| Source: |
Scientia |
| Publisher Information: |
Taylor & Francis |
| Publication Year: |
2024 |
| Subject Terms: |
Quimioteràpia combinada; Metàstasi; Pròstata - Càncer - Tractament; ANALYTICAL; DIAGNOSTIC AND THERAPEUTIC TECHNIQUES; AND EQUIPMENT::Therapeutics::Therapeutics::Drug Therapy::Antineoplastic Protocols::Therapeutics::Drug Therapy::Antineoplastic Combined Chemotherapy Protocols; DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms; Male::Prostatic Neoplasms::Prostatic Neoplasms; Castration-Resistant; Other subheadings::Other subheadings::Other subheadings::/drug therapy; AND EQUIPMENT::Investigative Techniques::Methods::Research Design; TÉCNICAS Y EQUIPOS ANALÍTICOS; DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapéutica::farmacoterapia::protocolos antineoplásicos::terapéutica::farmacoterapia::protocolos de quimioterapia antineoplásica combinada; ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata::neoplasias prostáticas resistentes a la castración; Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia; DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::métodos::diseño de la investigación |
| Description: |
Resumen; Cáncer de próstata metastásico ; Summary; Metastatic prostate cancer ; Resum; Càncer de pròstata metastàtic ; What is this summary about?: This summary is about the ongoing research study called TALAPRO-3. This study is testing the use of two medicines called talazoparib and enzalutamide. The two medicines are being used together as a treatment for patients with a type of cancer called metastatic castration-sensitive prostate cancer and changes in specific DNA repair genes within their tumors. The study began in May 2021, and includes 599 patients from 27 countries. What is metastatic castration-sensitive prostate cancer?: Metastatic castration-sensitive prostate cancer is known as mCSPC for short. It is cancer that has started in the prostate and spread to other body parts. The prostate is a gland below the bladder and helps make semen (the liquid that contains sperm). Castration-sensitive means that the cancer responds to treatments that lower testosterone in the blood. Which medicines are being tested?: In this study, some patients will take talazoparib plus enzalutamide while others will take a placebo plus enzalutamide. Talazoparib and enzalutamide are two different cancer medicines. Talazoparib is not currently used to treat patients with mCSPC. Enzalutamide is used to treat patients with prostate cancer. Talazoparib plus enzalutamide is being compared with a placebo plus enzalutamide to see if patients live longer without their cancer getting worse, or them dying, when taking talazoparib plus enzalutamide or when taking a placebo plus enzalutamide. What are the aims of the talapro-3 study?: This study aims to find out if treatment with talazoparib plus enzalutamide increases the length of time the patients in the study live without their cancer getting worse, or them dying, compared with treatment with a placebo plus enzalutamide. The study will also measure how long the patients in the study live, the number and types of side effects they have, their general health and quality of life, and ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Future Oncology;20(30); https://doi.org/10.1080/14796694.2024.2363131; https://hdl.handle.net/11351/12328; 001275972200001 |
| DOI: |
10.1080/14796694.2024.2363131 |
| Availability: |
https://hdl.handle.net/11351/12328; https://doi.org/10.1080/14796694.2024.2363131 |
| Rights: |
Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.19724B3B |
| Database: |
BASE |