| Title: |
Acta Biotheoretica Mathematical and philosophical foundations of biological and biomedical science A Conceptual Model of Morphogenesis and Regeneration |
| Authors: |
Tosenberger, Alen; Bessonov, Nikolai; Levin, M; Reinberg, Natalia; Volpert, Vitaly; Morozova, Nadya |
| Contributors: |
Multi-scale modelling of cell dynamics : application to hematopoiesis (DRACULA); Centre de génétique et de physiologie moléculaire et cellulaire (CGPhiMC); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Centre Inria de l'Université Grenoble Alpes; Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Institut Camille Jordan (ICJ); École Centrale de Lyon (ECL); Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon); Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)-École Centrale de Lyon (ECL); Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS); Modélisation mathématique, calcul scientifique (MMCS); Institut Camille Jordan (ICJ); Institute of Mechanical Engineering Problems St. Petersburg (IPME); Russian Academy of Sciences Moscow (RAS); Laboratorio de Biologia Molecular de la Enfermedad de Chagas Buenos Aires (LaBMECH); Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, “Dr. Héctor N. Torres” Buenos Aires (INGEBI); Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires (CONICET)-Facultad de Ciencias Exactas y Naturales Buenos Aires (FCEyN); Universidad de Buenos Aires Buenos Aires (UBA)-Universidad de Buenos Aires Buenos Aires (UBA)-Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires (CONICET)-Facultad de Ciencias Exactas y Naturales Buenos Aires (FCEyN); Universidad de Buenos Aires Buenos Aires (UBA)-Universidad de Buenos Aires Buenos Aires (UBA); Laboratoire Epigenetique et Cancer; Centre National de la Recherche Scientifique (CNRS) |
| Source: |
ISSN: 0001-5342. |
| Publisher Information: |
CCSD; Springer Verlag |
| Publication Year: |
2015 |
| Collection: |
Université Jean Monnet – Saint-Etienne: HAL |
| Subject Terms: |
[MATH.MATH-AP]Mathematics [math]/Analysis of PDEs [math.AP] |
| Description: |
International audience ; This paper is devoted to computer modelling of the development andregeneration of multicellular biological structures. Some species (e.g. planaria andsalamanders) are able to regenerate parts of their body after amputation damage, butthe global rules governing cooperative cell behaviour during morphogenesis are notknown. Here, we consider a simplified model organism, which consists of tissuesformed around special cells that can be interpreted as stemcells. We assume that stemcells communicate with each other by a set of signals, and that the values of thesesignals depend on the distance between cells. Thus the signal distribution characterizeslocation of stem cells. If the signal distribution is changed, then the difference betweenthe initial and the current signal distribution affects the behaviour of stem cells—e.g.as a result of an amputation of a part of tissue the signal distribution changes whichstimulates stem cells to migrate to new locations, appropriate for regeneration of theproper pattern. Moreover, as stem cells divide and form tissues around them, theycontrol the form and the size of regenerating tissues. This two-level organization of themodel organism, with global regulation of stem cells and local regulation of tissues,allows its reproducible development and regeneration. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1007/s10441-015-9249-9 |
| Availability: |
https://hal.science/hal-01237264; https://hal.science/hal-01237264v1/document; https://hal.science/hal-01237264v1/file/manuscript.pdf; https://doi.org/10.1007/s10441-015-9249-9 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.19986900 |
| Database: |
BASE |