| Title: |
Μελέτη της στόχευσης του συστήματος υαλουρονικού/CD44 στον καρκίνο ; Study of the targeting of hyaluronan/CD44 axis in cancer |
| Authors: |
Chatzopoulos, Athanasios; Χατζόπουλος, Αθανάσιος |
| Publisher Information: |
University of Patras; Πανεπιστήμιο Πατρών |
| Publication Year: |
2025 |
| Collection: |
National Archive of PhD Theses (National Documentation Centre Greece) |
| Subject Terms: |
Καρκίνος του μαστού; Πολύμορφο γλοιοβλάστωμα; Υαλουρονικό; CD44; HAS2; Ριβοσωμική πρωτεΐνη S6; 4-ΜU; Μακροκυκλικά πεπτίδια; Breast cancer; Glioblastoma multiforme; Ηyaluronan; Ribosomal protein S6; 4-MU; Macrocyclic peptides; Βιολογία; Φυσικές Επιστήμες; Βιοχημεία και Μοριακή βιολογία; Biological Sciences; Natural Sciences; Biochemistry and Molecular Biology |
| Description: |
The present thesis highlights the importance of targeting hyaluronan network in the development of more efficient therapeutic approaches against aggressive cancer (sub)types, such as triple negative breast cancer and gliomas. Breast cancer is characterized by high heterogeneity and can be classified based on the presence or absence of Estrogen Receptor α (ERα), Progesterone Receptor (PgR), and Human Epidermal Growth Factor Receptor 2 (HER2). The majority of breast cancer cases (~70%) express ERα and are associated with good prognosis due to the availability of effective hormonal therapies. On the other hand, breast cancer subtypes that do not express ERα (such as Triple Negative Breast Cancers, ERα-/PgR-/HER2-) are characterized by increased aggressiveness and poor prognosis. Glioma is the most common type of brain tumors in adults, accounting for 78% of brain cancers. The most aggressive form of gliomas is glioblastoma multiforme, which is considered the most prevalent primary brain cancer. Most patients with this disease die within a year of diagnosis despite multimodal treatment, due to the heterogeneity of the disease, its invasive nature, and its ability to resist chemotherapy. Hyaluronan is an unbranched heteropolysaccharide and constitutes one of the most important multifunctional components of the extracellular matrix. Its biosynthesis occurs at the cell membrane by hyaluronan synthase isoenzymes (HAS1, HAS2, and HAS3). Hyaluronan exerts its effects through interactions with cell surface receptors, such as the CD44 glycoprotein. The binding of hyaluronan to CD44 is a critical molecular interaction that regulates various physiological and pathological processes, including cancer. Given the significant role of hyaluronan network (hyaluronan synthases, hyaluronidases, and hyaluronan receptors) in cancer, the present PhD thesis focused on limiting the actions of the network by either hyaluronan biosynthesis inhibition or by preventing its binding to CD44. Previous studies by our research team have shown that ... |
| Document Type: |
doctoral or postdoctoral thesis |
| Language: |
Greek, Modern (1453-) |
| Relation: |
https://hdl.handle.net/10442/hedi/58715 |
| DOI: |
10.12681/eadd/58715 |
| Availability: |
https://hdl.handle.net/10442/hedi/58715; https://doi.org/10.12681/eadd/58715 |
| Accession Number: |
edsbas.19BCCE92 |
| Database: |
BASE |