Matching-adjusted indirect comparison of CPX- 351 in secondary Acute Myeloid Leukemia between the registrative trial and a real-life study
| Title: | Matching-adjusted indirect comparison of CPX- 351 in secondary Acute Myeloid Leukemia between the registrative trial and a real-life study |
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| Authors: | Fianchi L.; Piciocchi A.; Guolo F.; Marchesi F.; Marsili G.; Cattaneo C.; Gottardi M.; Restuccia F.; Candoni A.; Ortu La Barbera E.; Fazzi R.; Pasciolla C.; Finizio O.; Fracchiolla N.; Delia M.; Lessi F.; Dargenio M.; Bonuomo V.; Del Principe M. I.; Zappasodi P.; Picardi M.; Basilico C.; Piedimonte M.; Minetto P.; Chiusolo P.; Prezioso L.; Buquicchio C.; Melillo L.; Zama D.; Farina F.; Mancini V.; Rondoni M.; Busca A.; Pagano L. |
| Contributors: | Fianchi, L.; Piciocchi, A.; Guolo, F.; Marchesi, F.; Marsili, G.; Cattaneo, C.; Gottardi, M.; Restuccia, F.; Candoni, A.; Ortu La Barbera, E.; Fazzi, R.; Pasciolla, C.; Finizio, O.; Fracchiolla, N.; Delia, M.; Lessi, F.; Dargenio, M.; Bonuomo, V.; Del Principe, M. I.; Zappasodi, P.; Picardi, M.; Basilico, C.; Piedimonte, M.; Minetto, P.; Chiusolo, P.; Prezioso, L.; Buquicchio, C.; Melillo, L.; Zama, D.; Farina, F.; Mancini, V.; Rondoni, M.; Busca, A.; Pagano, L. |
| Publication Year: | 2025 |
| Collection: | IRIS Università degli Studi di Bologna (CRIS - Current Research Information System) |
| Subject Terms: | CPX- 351; Matching-adjusted indirect comparison; Secondary acute myeloid leukemia |
| Description: | A real-life study on CPX-351 and the standard arm (‘7 + 3’) of the CPX-351 registrative trial in adults with secondary Acute Myeloid Leukemia were compared by an unanchored Matching-adjusted indirect comparison (MAIC), in order to evaluate the efficacy and toxicity of CPX-351. Results of this study are important to confirm the role of CPX-351 in significantly improving survival and remission rates compared with ‘7 + 3’ with a good safety profile in AML patients with high-risk features, a target group traditionally with a very poor prognosis. Moreover, this pilot analysis underlines the potentiality of the statistical method to compare studies with strong differences. |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/40411596; info:eu-repo/semantics/altIdentifier/wos/WOS:001493606500001; volume:104; issue:5; firstpage:2731; lastpage:2736; numberofpages:6; journal:ANNALS OF HEMATOLOGY; https://hdl.handle.net/11585/1030573 |
| DOI: | 10.1007/s00277-025-06381-3 |
| Availability: | https://hdl.handle.net/11585/1030573; https://doi.org/10.1007/s00277-025-06381-3; https://link.springer.com/article/10.1007/s00277-025-06381-3 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY) ; license uri:iris.PUB15 |
| Accession Number: | edsbas.1A5243BC |
| Database: | BASE |