| Title: |
Enhancing the utility of antroduodenal manometry in pediatric intestinal pseudo‐obstruction |
| Authors: |
Chanpong, Atchariya; Cronin, Hannah; Rampling, Dyanne; Ashworth, Michael; Eaton, Simon; Rybak, Anna; Saliakellis, Efstratios; Lindley, Keith J.; Borrelli, Osvaldo; Thapar, Nikhil |
| Source: |
Neurogastroenterology & Motility ; volume 34, issue 5 ; ISSN 1350-1925 1365-2982 |
| Publisher Information: |
Wiley |
| Publication Year: |
2021 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Background Antroduodenal manometry (ADM) and histopathology are currently employed to aid the diagnosis of pediatric intestinal pseudo‐obstruction (PIPO). Limited data are available on the reliability of ADM analysis and its correlation with histopathology. We aimed to develop a protocol for enhanced analysis of ADM contractile patterns, including a scoring system, and explore whether this provided better correlation with histopathology. Methods Children referred with suspected PIPO between April 2012‐December 2019 who underwent both ADM and full‐thickness biopsies were included. ADM tracings were analyzed using both standard (conventional ADM) and novel (enhanced ADM) motility parameters. A novel ADM score (GLASS score) was generated based on the enhanced ADM analysis. Conventional and enhanced ADM analyses were then correlated with histopathology. Results Forty patients were included. Using conventional clinical criteria, 29 of these were diagnosed with PIPO and the other 11 with non‐PIPO diagnoses. Twenty‐three of the PIPO patients had abnormal histopathology: 6 myopathy, 4 neuropathy, 3 neuro‐myopathy, and 10 non‐specific changes. No agreement in diagnosis was found between conventional ADM analysis and histopathology (ϰ = 0.068; p = 0.197), whereas the latter significantly correlated with enhanced ADM analysis (ϰ = 0.191; p = 0.003). The enhanced ADM score was significantly higher in PIPO versus non‐PIPO (16.0 vs. 8.0; p < 0.001). Conclusions As opposed to conventional analysis protocols, the newly developed enhanced ADM analysis and associated score is not only able to discriminate between PIPO and non‐PIPO patients, but also between distinct histopathological pathologies. Further studies are required to assess the utility of enhanced ADM analysis in larger populations. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/nmo.14259 |
| Availability: |
https://doi.org/10.1111/nmo.14259; https://onlinelibrary.wiley.com/doi/pdf/10.1111/nmo.14259; https://onlinelibrary.wiley.com/doi/full-xml/10.1111/nmo.14259 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.1A526CF8 |
| Database: |
BASE |