Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure
| Title: | Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure |
|---|---|
| Authors: | Reynolds, Catherine J.; Pade, Corinna; Gibbons, Joseph M.; Otter, Ashley D.; Lin, Kai-Min; Muñoz Sandoval, Diana; Pieper, Franziska P.; Butler, David K.; Liu, Siyi; Joy, George; Forooghi, Nasim; Treibel, Thomas A.; Manisty, Charlotte; Moon, James C.; Semper, Amanda; Brooks, Tim; McKnight, Áine; Altmann, Daniel M.; Boyton, Rosemary J.; Abbass, Hakam; Abiodun, Aderonke; Alfarih, Mashael; Alldis, Zoe; Amin, Oliver E.; Andiapen, Mervyn; Artico, Jessica; Augusto, João B.; Baca, Georgina L.; Bailey, Sasha N. L.; Bhuva, Anish N.; Boulter, Alex; Bowles, Ruth; Bracken, Olivia V.; O’Brien, Ben; Bullock, Natalie; Captur, Gabriella; Carr, Olivia; Champion, Nicola; Chan, Carmen; Chandran, Aneesh; Coleman, Tom; Couto de Sousa, Jorge; Couto-Parada, Xose; Cross, Eleanor; Cutino-Moguel, Teresa; D’Arcangelo, Silvia; Davies, Rhodri H.; Douglas, Brooke; Di Genova, Cecilia; Dieobi-Anene, Keenan; Diniz, Mariana O.; Ellis, Anaya; Feehan, Karen; Finlay, Malcolm; Fontana, Marianna; Francis, Sasha; Gillespie, David; Gilroy, Derek; Hamblin, Matt; Harker, Gabrielle; Hemingway, Georgia; Hewson, Jacqueline; Heywood, Wendy; Hickling, Lauren M.; Hicks, Bethany; Hingorani, Aroon D.; Howes, Lee; Itua, Ivie; Jardim, Victor; Lee, Wing-Yiu Jason; Jensen, Melaniepetra; Jones, Jessica; Jones, Meleri; Kapil, Vikas; Kelly, Caoimhe; Kurdi, Hibba; Lambourne, Jonathan; Lloyd, Aaron; Louth, Sarah; Maini, Mala K.; Mandadapu, Vineela; Menacho, Katia; Mfuko, Celina; Mills, Kevin; Millward, Sebastian; Mitchelmore, Oliver; Moon, Christopher; Moon, James; Murray, Sam M.; Noursadeghi, Mahdad; Otter, Ashley; Palma, Susana; Parker, Ruth; Patel, Kush; Pawarova, Mihaela; Petersen, Steffen E.; Piniera, Brian; Rannigan, Lisa; Rapala, Alicja; Richards, Amy; Robathan, Matthew; Rosenheim, Joshua; Rowe, Cathy; Royds, Matthew; Sackville West, Jane; Sambile, Genine; Schmidt, Nathalie M.; Selman, Hannah; Seraphim, Andreas; Simion, Mihaela; Smit, Angelique; Sugimoto, Michelle; Swadling, Leo; Taylor, Stephen; Temperton, Nigel J.; Thomas, Stephen; Thornton, George D.; Tucker, Art; Varghese, Ann; Veerapen, Jessry; Vijayakumar, Mohit; Warner, Tim; Welch, Sophie; White, Hannah; Wodehouse, Theresa; Wynne, Lucinda; Zahedi, Dan; Chain, Benjamin |
| Publisher Information: | AAAS |
| Publication Year: | 2022 |
| Collection: | University of Kent: KAR - Kent Academic Repository |
| Subject Terms: | QR355 Virology |
| Description: | The Omicron, or Pango lineage B.1.1.529, variant of SARS-CoV-2 carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection from severe disease, often attributed to primed cellular immunity. We investigated T and B cell immunity against B.1.1.529 in triple mRNA vaccinated healthcare workers (HCW) with different SARS-CoV-2 infection histories. B and T cell immunity against previous variants of concern was enhanced in triple vaccinated individuals, but magnitude of T and B cell responses against B.1.1.529 spike protein was reduced. Immune imprinting by infection with the earlier B.1.1.7 (Alpha) variant resulted in less durable binding antibody against B.1.1.529. Previously infection-naïve HCW who became infected during the B.1.1.529 wave showed enhanced immunity against earlier variants, but reduced nAb potency and T cell responses against B.1.1.529 itself. Previous Wuhan Hu-1 infection abrogated T cell recognition and any enhanced cross-reactive neutralizing immunity on infection with B.1.1.529. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 0036-8075 |
| Relation: | https://kar.kent.ac.uk/95432/1/science.abq1841.pdf; Reynolds, Catherine J., Pade, Corinna, Gibbons, Joseph M., Otter, Ashley D., Lin, Kai-Min, Muñoz Sandoval, Diana, Pieper, Franziska P., Butler, David K., Liu, Siyi, Joy, George, and others. Forooghi, Nasim, Treibel, Thomas A., Manisty, Charlotte, Moon, James C., Semper, Amanda, Brooks, Tim, McKnight, Áine, Altmann, Daniel M., Boyton, Rosemary J., Abbass, Hakam, Abiodun, Aderonke, Alfarih, Mashael, Alldis, Zoe, Altmann, Daniel M., Amin, Oliver E., Andiapen, Mervyn, Artico, Jessica, Augusto, João B., Baca, Georgina L., Bailey, Sasha N. L., Bhuva, Anish N., Boulter, Alex, Bowles, Ruth, Boyton, Rosemary J., Bracken, Olivia V., O’Brien, Ben, Brooks, Tim, Bullock, Natalie, Butler, David K., Captur, Gabriella, Carr, Olivia, Champion, Nicola, Chan, Carmen, Chandran, Aneesh, Coleman, Tom, Couto de Sousa, Jorge, Couto-Parada, Xose, Cross, Eleanor, Cutino-Moguel, Teresa, D’Arcangelo, Silvia, Davies, Rhodri H., Douglas, Brooke, Di Genova, Cecilia, Dieobi-Anene, Keenan, Diniz, Mariana O., Ellis, Anaya, Feehan, Karen, Finlay, Malcolm, Fontana, Marianna, Forooghi, Nasim, Francis, Sasha, Gibbons, Joseph M., Gillespie, David, Gilroy, Derek, Hamblin, Matt, Harker, Gabrielle, Hemingway, Georgia, Hewson, Jacqueline, Heywood, Wendy, Hickling, Lauren M., Hicks, Bethany, Hingorani, Aroon D., Howes, Lee, Itua, Ivie, Jardim, Victor, Lee, Wing-Yiu Jason, Jensen, Melaniepetra, Jones, Jessica, Jones, Meleri, Joy, George, Kapil, Vikas, Kelly, Caoimhe, Kurdi, Hibba, Lambourne, Jonathan, Lin, Kai-Min, Liu, Siyi, Lloyd, Aaron, Louth, Sarah, Maini, Mala K., Mandadapu, Vineela, Manisty, Charlotte, McKnight, Áine, Menacho, Katia, Mfuko, Celina, Mills, Kevin, Millward, Sebastian, Mitchelmore, Oliver, Moon, Christopher, Moon, James, Muñoz Sandoval, Diana, Murray, Sam M., Noursadeghi, Mahdad, Otter, Ashley, Pade, Corinna, Palma, Susana, Parker, Ruth, Patel, Kush, Pawarova, Mihaela, Petersen, Steffen E., Piniera, Brian, Pieper, Franziska P., Rannigan, Lisa, Rapala, Alicja, Reynolds, Catherine J., Richards, Amy, Robathan, Matthew, Rosenheim, Joshua, Rowe, Cathy, Royds, Matthew, Sackville West, Jane, Sambile, Genine, Schmidt, Nathalie M., Selman, Hannah, Semper, Amanda, Seraphim, Andreas, Simion, Mihaela, Smit, Angelique, Sugimoto, Michelle, Swadling, Leo, Taylor, Stephen, Temperton, Nigel J., Thomas, Stephen, Thornton, George D., Treibel, Thomas A., Tucker, Art, Varghese, Ann, Veerapen, Jessry, Vijayakumar, Mohit, Warner, Tim, Welch, Sophie, White, Hannah, Wodehouse, Theresa, Wynne, Lucinda, Zahedi, Dan, Chain, Benjamin, and Moon, James C. (hide) (2022) Immune boosting by B.1.1.529 (Omicron) depends on previous SARS-CoV-2 exposure. Science, . ISSN 0036-8075. (doi:10.1126/science.abq1841 ) (KAR id:95432 ) |
| DOI: | 10.1126/science.abq1841 |
| Availability: | https://kar.kent.ac.uk/95432/; https://kar.kent.ac.uk/95432/1/science.abq1841.pdf; https://doi.org/10.1126/science.abq1841 |
| Rights: | cc_by |
| Accession Number: | edsbas.1A82338E |
| Database: | BASE |