| Title: |
Pneumococcal carriage following PCV13 delivered as one primary and one booster dose (1 + 1) compared to two primary doses and a booster (2 + 1) in UK infants |
| Authors: |
Goldblatt, David; Andrews, Nick J; Sheppard, Carmen L; Rose, Samuel; Aley, Parvinder K; Roalfe, Lucy; Southern, Jo; Robinson, Hannah; Pearce, Emma; Plested, Emma; Johnson, Marina; Litt, David J; Fry, Norman K; Waight, Pauline; Snape, Matthew D; Miller, Elizabeth |
| Source: |
Vaccine (2023) (In press). |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2023 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Vaccine Pneumococcal; Conjugate; Infant; Schedules |
| Description: |
In January 2020 the UK changed from a 2 + 1 schedule for 13-valent pneumococcal conjugate vaccine (PCV13) to a 1 + 1 schedule (doses at 3 and 12 months) based on a randomized immunogenicity trial comparing the two schedules. Carriage prevalence measured at the time of booster and 6 months later in 191 of the 213 study infants was 57 % (109/191) and 60 % (114/190) respectively. There were eight episodes of vaccine-type (VT) or vaccine-related 6C carriage in the 2 + 1 and six in the 1 + 1 group; ≥4-fold rises in serotype-specific IgG in 71 children with paired post-booster and follow up blood samples at 21–33 months of age were found in 20 % (7/35) of the 2 + 1 and 15 % (6/41) of the 1 + 1 group. VTs identified in carriage and inferred from serology were similar comprising 3, 19A and 19F. Dropping a priming dose from the 2 + 1 PCV 13 schedule did not increase VT carriage in the study cohort. Ongoing population level carriage studies will be important to confirm this. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10168198/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10168198/1/1-s2.0-S0264410X23004000-main.pdf; https://discovery.ucl.ac.uk/id/eprint/10168198/ |
| Rights: |
open |
| Accession Number: |
edsbas.1AEE00D |
| Database: |
BASE |