| Title: |
The Recent Emergence of Clostridium difficile Infection in Romanian Hospitals is Associated with a High Prevalence of Polymerase Chain Reaction Ribotype 027 |
| Authors: |
Popescu, Gabriel Adrian; Serban, Roxana; Pistol, Adriana; Niculcea, Andreea; Preda, Andreea; Lemeni, Daniela; Macovei, İoana Sabina; Tălăpan, Daniela; Rafila, Alexandru; Florea, Dragoş |
| Source: |
Volume: 35, Issue: 2191-195 ; 2146-3123 ; Balkan Medical Journal |
| Publisher Information: |
Trakya Üniversitesi; Trakya University |
| Publication Year: |
2018 |
| Collection: |
DergiPark Akademik (E-Journals) |
| Subject Terms: |
Clostridium difficile; epidemiology; ribotype 027; Romania |
| Description: |
Aims: To investigate the epidemiology of Clostridium difficile infection in Romanian hospitals.Methods: A survey was conducted at nine hospitals throughout Romania between November 2013 and February 2014.Results: The survey identified 393 patients with Clostridium difficile infection. The median age was 67 years (range: 2-94 years); 56% of patients were aged >65 years. The mean prevalence of Clostridium difficile infection was 5.2 cases per 10.000 patient-days. The highest prevalences were 24.9 and 20 per 10.000 patient-days in hospitals specializing in gastroenterology and infectious diseases, respectively. Clostridium difficile infections were health care-associated in 70.5% patients and community-acquired in 10.2%. The origin was not determined in 19.3%. Clostridium difficile infection was severe in 12.3% of patients, and the in-hospital all-cause mortality was 8.8%. Polymerase chain reaction ribotype 027 had the highest prevalence in all participating hospitals and represented 82.6% of the total ribotyped isolates. The minimum inhibitory concentration of moxifloxacin was >4 μg/mL for 59 of 80 tested isolates (73.8%). Of 59 isolates, 54 were highly resistant to moxifloxacin (minimum inhibitory concentration ≥32 μg/mL), and the majority were polymerase chain reaction ribotype 027 (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://dergipark.org.tr/tr/download/article-file/607552; https://dergipark.org.tr/tr/pub/bmj/issue/41631/502923 |
| Availability: |
https://dergipark.org.tr/tr/pub/bmj/issue/41631/502923 |
| Accession Number: |
edsbas.1B23FDF3 |
| Database: |
BASE |