| Title: |
Key factors associated with pulmonary sequelae in the follow-up of critically ill COVID-19 patients |
| Authors: |
Pérez García, Felipe; González, Jessica; Batlle García, Jordi de; Benítez, Iván D.; Torres, Gerard; Santisteve, Sally; Targa Dias Santos, Adriano; Gort Paniello, Clara; Moncusí Moix, Anna; Aguilà Balastegui, Maria; Seck, Fatty; Ceccato, Adrián; Ferrer Roca, Ricard; Motos, Anna; Riera del Brío, Jordi; Fernández Barat, Laia; Menéndez, Rosario; Lorente Balanza, José Ángel; Peñuelas, Oscar; García Gasulla, Darío; Peñasco Martín, Yhivian; Ricart Martí, Pilar; Abril Palomares, Elena; Aguilera, Luciano; Rodriguez, Alejandro; Boado Varela, María Victoria; Beteré Cubillo, Belén; Pozo Laderas, Juan Carlos; Solé Violan, Jordi; Salvador Adell, Inmaculada; Andrea Novo, Mariana; Barberán, José; Amaya Villar, Rosario; Garnacho Montero, José; Gómez, José M.; Blandino Ortiz, Aaron Rolando; Tamayo Lomas, Luis; Úbeda Iglesias, Alejandro; Catalán González, Mercedes; Sánchez Miralles, Angel; Martínez Varela, Ignacio; Jorge García, Ruth Noemí; Franco, Nieves; Gumucio Sanguino, Victor Daniel; Bustamante Munguira, Elena; Valdivia, Luis Jorge; Caballero, Jesús; Gallego Curto, Elena; Rodríguez, Covadonga; Castellanos Ortega, Álvaro; Trenado, Josep; Marin Corral, Judith; Muñiz Albaiceta, Guillermo; Torre, María del Carmen de la; Loza Vázquez, Ana; Vidal Cortés, Pablo; Añón Elizalde, José Manuel; Carbajales Pérez, Cristina; Sagredo Meneses, Víctor; Carbonell Monleón, Cristina; Socias Crespí, Lorenzo; Barberà, Carme; Estella, Ángel; Díaz, Emilio; Gonzalo Calvo, David de; Torres, Antoni; Barbé Illa, Ferran |
| Contributors: |
Universidad de Alcalá. Departamento de Biomedicina y Biotecnología; Unidad Docente Microbiología y Parasitología |
| Publication Year: |
2023 |
| Collection: |
e_Buah - Biblioteca Digital de la Universidad de Alcalá |
| Subject Terms: |
COVID-19; CT abnormalities; ICU; Lung function; Sequelae; Medicina; Medicine |
| Description: |
11 p. ; Introduction: Critical COVID-19 survivors have a high risk of respiratory sequelae. Therefore, we aimed to identify key factors associated with altered lung function and CT scan abnormalities at a follow-up visit in a cohort of critical COVID-19 survivors. Methods: Multicenter ambispective observational study in 52 Spanish intensive care units. Up to 1327 PCR-con rmed critical COVID-19 patients had sociodemographic, anthropometric, comorbidity and lifestyle characteristics collected at hospital admission; clinical and biological parameters throughout hospital stay; and, lung function and CT scan at a follow-up visit. Results: The median [p25?p75] time from discharge to follow-up was 3.57 [2.77?4.92] months. Median age was 60 [53?67] years, 27.8% women. The mean (SD) percentage of predicted diffusing lung capacity for carbon monoxide (DLCO) at follow-up was 72.02 (18.33)% predicted, with 66% of patients having DLCO< 80% and 24% having DLCO< 60%. CT scan showed persistent pulmonary in ltrates, brotic lesions, and emphysema in 33%, 25% and 6% of patients, respectively. Key variables associated with DLCO< 60% were chronic lung disease (CLD) (OR: 1.86 (1.18?2.92)), duration of invasive mechanical ventilation (IMV) (OR: 1.56 (1.37?1.77)), age (OR [per-1-SD] (95%CI): 1.39 (1.18?1.63)), urea (OR: 1.16 (0.97?1.39)) and estimated glomerular ltration rate at ICU admission (OR: 0.88 (0.73?1.06)). Bacterial pneumonia (1.62 (1.11?2.35)) and duration of ventilation (NIMV (1.23 (1.06?1.42), IMV (1.21 (1.01?1.45)) and prone positioning (1.17 (0.98?1.39)) were associated with brotic lesions. Conclusion: Age and CLD, re ecting patients? baseline vulnerability, and markers of COVID-19 severity, such as duration of IMV and renal failure, were key factors associated with impaired DLCOand CT abnormalities. ; Instituto de Salud Carlos III ; Centro de Investigación Biomédica en Red ; Enfermedades Respiratorias ; Fundación Francisco Soria Melguizo ; FEDER |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
info:eu-repo/grantAgreement/ISCIII//CIBERESUCICOVID/ES//; info:eu-repo/grantAgreement/ISCIII//COV20/00110/ES//; info:eu-repo/grantAgreement/ISCIII//CP19/00108/ES//; info:eu-repo/grantAgreement/ISCIII//CP20/00041/ES//; info:eu-repo/grantAgreement/ISCIII//CD21/00087/ES//; https://hdl.handle.net/10017/60935; AR/0000047124; Archivos de Bronconeumologia; 59; 215; 205 |
| DOI: |
10.1016/j.arbres.2022.12.017 |
| Availability: |
https://hdl.handle.net/10017/60935; https://doi.org/10.1016/j.arbres.2022.12.017 |
| Rights: |
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.1B34B659 |
| Database: |
BASE |