| Title: |
Distinct memory CD4 + T cell subset tropism of two CCR5-tropic HIV-1 in a rapid progressor |
| Authors: |
Marichannegowda, Manukumar Honnayakanahalli; Farah, Yasmine; Bose, Meera; Sanders-Buell, Eric; King, David; Francisco, Leilani; Eller, Leigh Anne; Rashid, Abdur; Tovanabutra, Sodsai; Michael, Nelson L.; Robb, Merlin L.; Song, Hongshuo |
| Contributors: |
Moore, Nicholas M.; National Institutes of Health |
| Source: |
ASM Case Reports ; volume 1, issue 6 ; ISSN 2996-2684 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2025 |
| Description: |
Background Low HIV-1 infection level in the central memory CD4 + T cell subset is a hallmark of both non-progressive HIV infection and non-pathogenetic SIV infection in the natural hosts. However, an important gap in knowledge is whether CCR5-tropic HIV-1 variants have different memory CD4 + T cell subset preferences. Case Summary Here, we identified clear compartmentalization of two CCR5-tropic HIV-1 in different memory CD4 + T cell subsets in a rapid progressor. Participant 40512 was identified in the RV217 cohort. While the transmitted/founder (T/F) virus in 40512 was compartmentalized in the central memory CD4 + T cells, the superinfecting virus was compartmentalized in the effector memory CD4 + T cells. Both viruses rely on CCR5 to infect primary CD4 + T cells. The T/F virus is more than 100-fold more resistant to the CCR5 inhibitor Maraviroc than the superinfecting virus. Conclusion This case report demonstrates that CCR5 HIV-1 variants have distinct memory CD4 + T cell subset preferences in vivo . Because CD4 + T cell subset targeting is highly relevant for HIV-1 pathogenesis, understanding the underlying molecular mechanisms may provide deeper insights into HIV-1 therapeutics and functional cure. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/asmcr.00101-25 |
| Availability: |
https://doi.org/10.1128/asmcr.00101-25; https://journals.asm.org/doi/pdf/10.1128/asmcr.00101-25 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.1B789811 |
| Database: |
BASE |