| Title: |
Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women. |
| Authors: |
Ho, PJ; Loo, CKY; Lim, RJY; Goh, MH; Abubakar, M; Ahearn, TU; Andrulis, IL; Antonenkova, NN; Aronson, KJ; Augustinsson, A; Behrens, S; Bodelon, C; Bogdanova, NV; Bolla, MK; Brantley, KD; Brenner, H; Byers, H; Camp, NJ; Castelao, JE; Cessna, MH; Chang-Claude, J; Chanock, SJ; Chenevix-Trench, G; Choi, J-Y; Colonna, SV; Czene, K; Daly, MB; Derouane, F; Dörk, T; Eliassen, AH; Engel, C; Eriksson, M; Evans, DG; Fletcher, O; Fritschi, L; Gago-Dominguez, M; Genkinger, JM; Geurts-Giele, WRR; Glendon, G; Hall, P; Hamann, U; Ho, CYS; Ho, W-K; Hooning, MJ; Hoppe, R; Howell, A; Humphreys, K; Ito, H; Iwasaki, M; Jakubowska, A; Jernström, H; John, EM; Johnson, N; Kang, D; Kim, S-W; Kitahara, CM; Ko, Y-D; Kraft, P; Kwong, A; Lambrechts, D; Larsson, S; Li, S; Lindblom, A; Linet, M; Lissowska, J; Lophatananon, A; MacInnis, RJ; Mannermaa, A; Manoukian, S; Margolin, S; Matsuo, K; Michailidou, K; Milne, RL; Mohd Taib, NA; Muir, KR; Murphy, RA; Newman, WG; O'Brien, KM; Obi, N; Olopade, OI; Panayiotidis, MI; Park, SK; Park-Simon, T-W; Patel, AV; Peterlongo, P; Plaseska-Karanfilska, D; Pylkäs, K; Rashid, MU; Rennert, G; Rodriguez, J; Saloustros, E; Sandler, DP; Sawyer, EJ; Scott, CG; Shahi, S; Shu, X-O; Shulman, K; Simard, J; Southey, MC; Stone, J; Taylor, JA; Teo, S-H; Teras, LR; Terry, MB; Torres, D; Vachon, CM; Houdt, MV; Verhoeven, J; Weinberg, CR; Wolk, A; Yamaji, T; Yip, CH; Zheng, W; Hartman, M; Li, J; On Behalf Of The Abctb Investigators; kConFab Investigators; MyBrCa Investigators; Sgbcc Investigators |
| Contributors: |
Fletcher, Olivia; Johnson, Nichola |
| Publisher Information: |
MDPI |
| Publication Year: |
2026 |
| Collection: |
The Institute of Cancer Research (ICR): Publications Repository |
| Subject Terms: |
BRCA1; BRCA2; Gail model; breast cancer; ductal carcinoma in situ (DCIS); polygenic risk score (PRS); risk stratification; risk-based screening |
| Subject Geographic: |
Switzerland |
| Description: |
Background: Breast cancer polygenic risk scores (PRS) and traditional risk models (e.g., the Gail model [Gail]) are known to contribute largely independent information, but it is unclear how the overlap varies by ancestry, age, disease type (invasive breast cancer, DCIS), and risk threshold. Methods: In a retrospective case-control study, we evaluated risk prediction performance in 180,398 women (161,849 of European ancestry; 18,549 of Asian ancestry). Odds ratios (ORs) from logistic regression models and the area under the receiver operating characteristic curve (AUC) were estimated. Results: PRS for invasive disease showed a stronger association in younger ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
Electronic; application/pdf |
| Language: |
English |
| ISSN: |
2072-6694 |
| Relation: |
ARTN 3561; cancers17213561; Cancers, 2025, 17 (21), pp. 3561 -; https://repository.icr.ac.uk/handle/internal/7580 |
| DOI: |
10.3390/cancers17213561 |
| Availability: |
https://doi.org/10.3390/cancers17213561; https://repository.icr.ac.uk/handle/internal/7580 |
| Rights: |
http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.1BDD57D8 |
| Database: |
BASE |