| Title: |
COVID-19 infection among patients with autoinflammatory diseases: a study on 117 French patients compared with 1545 from the French RMD COVID-19 cohort: COVIMAI - the French cohort study of SARS-CoV-2 infection in patient with systemic autoinflammatory diseases. |
| Authors: |
Bourguiba, Rim; Kyheng, MaÉva; Koné-Paut, Isabelle; Rouzaud, Diane; Avouac, Jérôme; Devaux, Mathilde; Abdallah, Nassim A.; Fautrel, Bruno; Ferreira-Maldent, Nicole; Langlois, Vincent; Ledoult, Emmanuel; Nielly, Hubert; Queyrel, Viviane; Sellam, Jérémie; Tieulie, Nathalie; Chazerain, Pascal; Evon, Philippe; Labreuche, Julien; Savey, Léa; Hentgen, Véronique; Grateau, Gilles; Georgin-Lavialle, Sophie |
| Contributors: |
Université de Lille; CHU Lille; CHU Tenon AP-HP; Evaluation des technologies de santé et des pratiques médicales - ULR 2694 METRICS; AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre); AP-HP - Hôpital Bichat - Claude Bernard Paris; Hôpital Cochin AP-HP; Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS Poissy; Hopital Saint-Louis AP-HP AP-HP; Pharmacoépidémiologie et évaluation des soins iPLesp PEPITES; Centre Hospitalier Régional Universitaire de Tours CHRU Tours; Groupe Hospitalier du Havre Hôpital Jacques Monod (MONTIVILLIERS) GHH; Centre National de Référence des Maladies Auto-Immunes Systémiques Rares du Nord et Nord-Ouest de France CeRAINO; Hôpital d'Instruction des Armées Begin; Centre Hospitalier Universitaire de Nice CHU Nice; Centre de Recherche Saint-Antoine UMRS893; Groupe Hospitalier Diaconesses Croix Saint-Simon; Université Lille Nord (France); Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses CH Versailles CeRéMAIA - Hôpital André Mignot |
| Publication Year: |
2024 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Subject Terms: |
familial Mediterranean fever; biological therapy; autoimmune diseases; COVID-19 |
| Description: |
Objective There is little known about SARS-CoV-2 infection in patients with systemic autoinflammatory disease (SAID). This study aimed to describe epidemiological features associated with severe disease form and death. Mortality between patients with and without SAID hospitalised for SARS-CoV-2 infection was compared. Methods A national multicentric prospective cohort study was conducted from the French Rheumatic and Musculoskeletal Diseases (RMD) COVID-19 cohort. Patients with SAID were matched with patients with non-SAID on age±7 years, gender and number of comorbidities to consider important confounding factors. Impact of SAID on severity of SARS-CoV-2 infection was analysed using multinomial logistic regression for severity in three classes (mild, moderate and severe with mild status as reference). Fine-Gray regression model for length of hospital stay and binomial logistic regression model for risk of death at 30 days. Results We identified 117 patients with SAID (sex ratio 0.84, 17 children) and compared them with 1545 patients with non-autoinflammatory immune-mediated inflammatory disorders (non-SAID). 67 patients had a monogenic SAID (64 with familial Mediterranean fever). Other SAIDs were Behçet' disease (n=21), undifferentiated SAID (n=16), adult-onset Still disease (n=9) and systemic-onset juvenile idiopathic arthritis (n=5). Ten adults developed severe form (8.6%). Six patients died. All children had a benign disease. After matching on age±7 years, sex and number of comorbidities, no significant difference between the two groups in length of stay and the severity of infection was noted. Conclusion As identified in the whole French RMD COVID-19 cohort, patients with SAID on corticosteroids and with multiple comorbidities are prone to develop more severe COVID-19 forms. ; 8 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/rdf+xml; charset=utf-8; application/pdf |
| Language: |
English |
| Relation: |
RMD Open : Rheumatic & Musculoskeletal Diseases; RMD Open; http://hdl.handle.net/20.500.12210/90091 |
| Availability: |
https://hdl.handle.net/20.500.12210/90091 |
| Rights: |
Attribution-NonCommercial 3.0 United States ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.1C31BA6E |
| Database: |
BASE |