| Title: |
Emerging Immunotherapy Targets in Early Drug Development |
| Authors: |
Morchón-Araujo, Daniel; Catani, Greta; Mirallas, Oriol; Pretelli, Giulia; Sánchez-Pérez, Vicky; Vieito, María; Braña, Irene; Pujol-Borrell, Ricardo; Garralda, Elena; Hernando-Calvo, Alberto |
| Publication Year: |
2025 |
| Collection: |
Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| Subject Terms: |
Immunotherapy; Phase 1 trial; Early drug development; Checkpoint inhibitors; Bispecific antibodies; Tumor microenvironment |
| Description: |
Immunotherapy has significantly changed the treatment paradigm for solid tumors, with immune checkpoint inhibitors now established in the management of many malignancies. Despite initial success, durable responses remain limited to a subset of patients, often less than 30%, due to both intrinsic and acquired resistance mechanisms. These challenges have prompted the development of next-generation immunotherapies. Recent efforts have expanded the scope of immunotherapy beyond PD-1/PD-L1 and CTLA-4 inhibition, focusing on new immune targets currently under investigation in early phase clinical trials. These include novel immune checkpoint inhibitors, immunomodulators targeting the tumor microenvironment, and bispecific antibodies. This review provides a comprehensive overview of emerging immune targets currently being investigated in early drug development, discussing their mechanisms of action, preliminary clinical outcomes, and potential future directions. |
| Document Type: |
other/unknown material |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
14220067; 12155519 |
| Relation: |
"la Caixa" Foundation LCF/PR/CE07/50610001; International journal of molecular sciences; Vol. 26 Núm. 11 (june 2025), p. 5394; https://ddd.uab.cat/record/313628; urn:10.3390/ijms26115394; urn:oai:ddd.uab.cat:313628; urn:scopus_id:105007690204; urn:articleid:14220067v26n11p5394; urn:pmid:40508202; urn:pmcid:PMC12155519; urn:oai:pubmedcentral.nih.gov:12155519 |
| Availability: |
https://ddd.uab.cat/record/313628 |
| Rights: |
open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.1C5D1A00 |
| Database: |
BASE |