| Title: |
Transcriptomic Signature Differences Between SARS-CoV-2 and Influenza Virus Infected Patients |
| Authors: |
Stéphanie Bibert; Nicolas Guex; Joao Lourenco; Thomas Brahier; Matthaios Papadimitriou-Olivgeris; Lauro Damonti; Oriol Manuel; Robin Liechti; Lou Götz; Jonathan Tschopp; Mathieu Quinodoz; Peter Vollenweider; Jean-Luc Pagani; Mauro Oddo; Olivier Hügli; Frédéric Lamoth; Véronique Erard; Cathy Voide; Mauro Delorenzi; Nathalie Rufer; Fabio Candotti; Carlo Rivolta; Noémie Boillat-Blanco; Pierre-Yves Bochud; the RegCOVID Study Group; Bochud Pierre-Yves; Desgranges Florian; Filippidis Paraskevas; Guéry Benoit; Haefliger David; Kampouri Eleftheria-Evdokia; Manuel Oriol; Munting Aline; Pagani Jean-Luc; Papadimitriou-Olivgeris Matthaios; Regina Jean; Rochat-Stettler Laurence; Suttels Veronique; Tadini Eliana; Tschopp Jonathan; Van Singer Mathias; Viala Benjamin; Vollenweider Peter |
| Source: |
Frontiers in Immunology, Vol 12 (2021) |
| Publisher Information: |
Frontiers Media S.A. |
| Publication Year: |
2021 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
COVID-19; SARS-CoV-2; influenza; whole blood transcriptome; RNA-sequencing; immune profiling; Immunologic diseases. Allergy; RC581-607 |
| Description: |
The reason why most individuals with COVID-19 have relatively limited symptoms while other develop respiratory distress with life-threatening complications remains unknown. Increasing evidence suggests that COVID-19 associated adverse outcomes mainly rely on dysregulated immunity. Here, we compared transcriptomic profiles of blood cells from 103 patients with different severity levels of COVID-19 with that of 27 healthy and 22 influenza-infected individuals. Data provided a complete overview of SARS-CoV-2-induced immune signature, including a dramatic defect in IFN responses, a reduction of toxicity-related molecules in NK cells, an increased degranulation of neutrophils, a dysregulation of T cells, a dramatic increase in B cell function and immunoglobulin production, as well as an important over-expression of genes involved in metabolism and cell cycle in patients infected with SARS-CoV-2 compared to those infected with influenza viruses. These features also differed according to COVID-19 severity. Overall and specific gene expression patterns across groups can be visualized on an interactive website (https://bix.unil.ch/covid/). Collectively, these transcriptomic host responses to SARS-CoV-2 infection are discussed in the context of current studies, thereby improving our understanding of COVID-19 pathogenesis and shaping the severity level of COVID-19. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.666163/full; https://doaj.org/toc/1664-3224; https://doaj.org/article/031b1be15a7044fbb009c5558ae5426c |
| DOI: |
10.3389/fimmu.2021.666163 |
| Availability: |
https://doi.org/10.3389/fimmu.2021.666163; https://doaj.org/article/031b1be15a7044fbb009c5558ae5426c |
| Accession Number: |
edsbas.1C68D2ED |
| Database: |
BASE |