| Title: |
Association Between Post‐Partum Anaemia and Depressive Symptoms at Two Months After Vaginal Delivery: A Secondary Analysis of the TRAAP Trial |
| Authors: |
Loussert, Lola; Sentilhes, Loïc; Froeliger, Alizée; Seco, Aurélien; Bonnet, Marie Pierre; Tebeka, Sarah; Deneux‐tharaux, Catherine |
| Contributors: |
Obstetrical, Perinatal and Pediatric Epidemiology; Centre for Research in Epidemiology and Statistics; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Service Gynécologie CHU Toulouse; Pôle Femme-Mère-Couple CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse) |
| Source: |
ISSN: 1470-0328 ; EISSN: 1471-0528. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2025 |
| Subject Terms: |
maternal mental health; post-partum anaemia; post-partum depression; post-partum haemoglobin level; vaginal delivery; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; ABSTRACT Objective To assess the association between maternal haemoglobinaemia in the immediate post‐partum period and PPD symptoms 2 months after vaginal delivery. Design Ancillary cohort study of the TRAAP trial, a multicentre trial. Setting In France, 2015–2016. Population Women with a singleton pregnancy and vaginal delivery ≥ 35 weeks. We excluded women with known psychiatric conditions and those who were non‐respondent to the Edinburgh Post‐partum Depression Scale (EPDS) questionnaire. Methods The exposure was immediate post‐partum haemoglobinemia (systematically collected in TRAAP trial) as a continuous variable. Main Outcome PPD symptoms at 2 months post‐partum, defined as an EPDS score ≥ 11. We also differentiated two levels of PPD symptom severity: moderate (11 ≤ EPDS < 13) and severe (EPDS ≥ 13) depressive symptoms. Results Amongst the 2672 women included, 1115 (43.6%) had post‐partum anaemia (haemoglobin < 11 g/dL) in the immediate post‐partum and 369 (13.8%) had PPD symptoms at 2 months. The relation between haemoglobin and PPD symptoms was linear. In the multivariable analysis, each 1 g/dL increase in haemoglobin level was associated with a 9% decrease in the risk of post‐partum depression symptoms (adjusted Relative Risk 0.91; 95% CI 0.82–0.997). Post‐partum haemoglobin was specifically associated with moderate depressive symptoms (adjusted Relative Risk 0.84; 95% CI, 0.72–0.98) but not with severe depressive symptoms (aRR 0.95; 95% CI, 0.84–1.07). Conclusions In women with vaginal delivery, each 1 g/dL increase in haemoglobin level was associated with a 9% decrease in the risk of post‐partum depression symptoms. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/1471-0528.18289 |
| Availability: |
https://hal.science/hal-05165683; https://hal.science/hal-05165683v1/document; https://hal.science/hal-05165683v1/file/BJOG%20-%202025%20-%20Loussert%20-%20Association%20Between%20Post%E2%80%90Partum%20Anaemia%20and%20Depressive%20Symptoms%20at%20Two%20Months%20After%20Vaginal.pdf; https://doi.org/10.1111/1471-0528.18289 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.1CC26DD |
| Database: |
BASE |