| Title: |
Anxiety, depression, physical disease parameters and health-related quality of life in the BronchUK national bronchiectasis cohort |
| Authors: |
De Soyza A; Saunders T; Wild G; Mawson P; Kelly M; Elborn S; Hill AT; Gatheral T; Sullivan A; Haworth C; Hurst JR; Brown J; Carroll M; Navaratnam V; Loebinger M; Davies G; Upadhyay H; Bradley J; Walker PP; Steer J; Duckers J; Pollock J; Crichton M; Chalmers JD; McNally R |
| Source: |
ERJ Open Research, May 2025 |
| Publisher Information: |
European Respiratory Society |
| Publication Year: |
2025 |
| Collection: |
Newcastle University Library ePrints Service |
| Description: |
©The authors 2025. Background: Bronchiectasis is associated with psychological comorbidity and poor quality of life (QoL), yet guidelines lack focus on psychological morbidity. Using data obtained from the BronchUK database (1341 patients), we examined the link between anxiety/depression and physical disease severity, QoL and long-term outcomes in bronchiectasis. Methods: Computed tomography-confirmed bronchiectasis patients enrolled in the BronchUK study with Hospital Anxiety and Depression Scale (HADS-A/D) data were studied. HADS-A/D scores ⩾8 indicated anxiety/depression. QoL was measured by the St George’s Respiratory Questionnaire and QoL-Bronchiectasis Questionnaire. Exacerbations during annual follow-up were analysed by negative binomial regression with time in study as an offset adjusted for age, body mass index, sex, Pseudomonas infection, diabetes and forced expiratory volume in 1 s (FEV1). Cox regression determined probability of hospitalisation using time to first exacerbation. Results 1341 patients were included; 418 had anxiety (31%), 269 (20%) had depression and 201 (15%) had both conditions. HADS-A/D ⩾8 was associated with worse QoL (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://eprints.ncl.ac.uk/306299; https://eprints.ncl.ac.uk/fulltext.aspx?url=306299/B94A7BD9-6D16-4123-9E4B-9631E7DD3552.pdf&pub_id=306299 |
| DOI: |
10.57711/gg71-6m68 |
| Availability: |
https://doi.org/10.57711/gg71-6m68; https://eprints.ncl.ac.uk/306299 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.1CD7B59F |
| Database: |
BASE |