| Title: |
Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction |
| Authors: |
Marschner, Rafael Aguiar; Banda, Patrícia Da Silva; Wajner, Simone Magagnin; Markoski, Melissa Medeiros; Schaun, Maximiliano Isoppo; Lehnen, Alexandre Machado |
| Publication Year: |
2019 |
| Collection: |
Universidade Federal do Rio Grande do Sul (UFRGS): Lume |
| Subject Terms: |
Exercício físico; Infarto do miocárdio; Antioxidantes; Myocardial infarction; Exercise; Cardiovascular physiology; Antioxidants; Oxidation-reduction reactions; Sedentary behavior; Glutathione; Oxidative stress |
| Description: |
Aims: We assessed the effects of a short-term exercise training on cardiac function, oxidative stress markers, and type 3 iodothyronine deiodinase (D3) activity in cardiac tissue of spontaneously hypertensive rats (SHR) following experimental myocardial infarction (MI). Methods: Twenty-four SHR (aged 3 months) were allocated to 4 groups: sham+sedentary, sham+trained, MI+sedentary and MI+trained. MI was performed by permanent ligation of the coronary artery. Exercise training (treadmill) started 96 hours after MI and lasted for 4 weeks (~60% maximum effort, 4x/week and 40 min/day). Cardiac function (echocardiography), thioredoxin reductase (TRx), total carbonyl levels, among other oxidative stress markers and D3 activity were measured. A Generalized Estimating Equation was used, followed by Bonferroni’s test (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
PloS one. San Francisco. Vol. 14, no. 9 (Sept. 2019), e0222334, 15 p.; https://hdl.handle.net/10183/220765; 001122970 |
| Availability: |
https://hdl.handle.net/10183/220765 |
| Rights: |
Open Access |
| Accession Number: |
edsbas.1CF82718 |
| Database: |
BASE |