| Title: |
Regulation of mTOR, Metabolic Fitness, and Effector Functions by Cytokines in Natural Killer Cells |
| Authors: |
Viel, Sébastien; Besson, Laurie; Marotel, Marie; Walzer, Thierry; Marçais, Antoine |
| Contributors: |
Réponse immunitaire innée dans les maladies infectieuses et auto-immunes – Innate immunity in infectious and autoimmune diseases CIRI; Centre International de Recherche en Infectiologie (CIRI); École normale supérieure de Lyon (ENS de Lyon); Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon); Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS); Laboratoire d’Immunologie HCL, Lyon; Centre Hospitalier Lyon Sud CHU - HCL (CHLS); Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL) |
| Source: |
ISSN: 2072-6694. |
| Publisher Information: |
CCSD; MDPI |
| Publication Year: |
2017 |
| Collection: |
Université Jean Monnet – Saint-Etienne: HAL |
| Subject Terms: |
TGF-β; NK cells; mTOR; metabolism; IL-15; [SDV.IMM]Life Sciences [q-bio]/Immunology; [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology; [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology |
| Description: |
International audience ; The control of cellular metabolism is now recognized as key to regulate functional properties of immune effectors such as T or Natural Killer (NK) cells. During persistent infections or in the tumor microenvironment, multiple metabolic changes have been highlighted in T cells that contribute to their dysfunctional state or exhaustion. NK cells may also undergo major phenotypic and functional modifications when infiltrating tumors that could be linked to metabolic alterations. The mammalian target of rapamycin (mTOR) kinase is a central regulator of cellular metabolism. mTOR integrates various extrinsic growth or immune signals and modulates metabolic pathways to fulfill cellular bioenergetics needs. mTOR also regulates transcription and translation thereby adapting cellular pathways to the growth or activation signals that are received. Here, we review the role and regulation of mTOR in NK cells, with a special focus on cytokines that target mTOR such as IL-15 and TGF-β. We also discuss how NK cell metabolic activity could be enhanced or modulated to improve their effector anti-tumor functions in clinical settings. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28956813; PUBMED: 28956813; PUBMEDCENTRAL: PMC5664071 |
| DOI: |
10.3390/cancers9100132 |
| Availability: |
https://hal.science/hal-01911304; https://hal.science/hal-01911304v1/document; https://hal.science/hal-01911304v1/file/main.pdf; https://doi.org/10.3390/cancers9100132 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.1D3FF10E |
| Database: |
BASE |