| Title: |
Pituitary T1 signal intensity at magnetic resonance imaging is reduced in patients with obesity: results from the CHIASM study |
| Authors: |
Puliani G.; Sbardella E.; Cozzolino A.; Sada V.; Tozzi R.; Andreoli C.; Fiorelli M.; Di Biasi C.; Corallino D.; Balla A.; Paganini A. M.; Venneri M. A.; Lenzi A.; Lubrano C.; Isidori A. M. |
| Contributors: |
Puliani, G.; Sbardella, E.; Cozzolino, A.; Sada, V.; Tozzi, R.; Andreoli, C.; Fiorelli, M.; Di Biasi, C.; Corallino, D.; Balla, A.; Paganini, A. M.; Venneri, M. A.; Lenzi, A.; Lubrano, C.; Isidori, A. M. |
| Publisher Information: |
Springer Nature; CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND |
| Publication Year: |
2023 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
obesity; pituitary; magnetic resonance imaging |
| Description: |
Background: Despite obesity being well known to be associated with several pituitary hormone imbalances, pituitary appearance in magnetic resonance imaging (MRI) in patients with obesity is understudied. Objective: To evaluate the pituitary volume and signal intensity at MRI in patients with obesity. Methods: This is a prospective study performed in an endocrine Italian referral center (ClinicalTrial.gov Identifier: NCT03458533). Sixty-nine patients with obesity (BMI > 30 kg/m2) and twenty-five subjects without obesity were enrolled. Thirty-three patients with obesity were re-evaluated after 3years of diet and lifestyle changes, of whom 17 (51.5%) achieved a > 5% loss of their initial body weight, whereas the remaining 16 (48.5%) had maintained or gained weight. Evaluations included metabolic and hormone assessments, DEXA scan, and pituitary MRI. Pituitary signal intensity was quantified by measuring the pixel density using ImageJ software. Results: At baseline, no difference in pituitary volume was observed between the obese and non-obese cohorts. At the 3-year follow-up, pituitary volume was significantly reduced (p = 0.011) only in participants with stable-increased body weight. Furthermore, a significant difference was noted in the mean pituitary intensity of T1-weighted plain and contrast-enhanced sequences between the obese and non-obese cohorts at baseline (p = 0.006; p = 0.002), and a significant decrease in signal intensity was observed in the subgroup of participants who had not lost weight (p = 0.012; p = 0.017). Insulin-like growth factor-1 levels, following correction for BMI, were correlated with pituitary volume (p = 0.001) and intensity (p = 0.049), whereas morning cortisol levels were correlated with pituitary intensity (p = 0.007). The T1-weighted pituitary intensity was negatively correlated with truncal fat (p = 0.006) and fibrinogen (p = 0.018). Conclusions: The CHIASM study describes a quantitative reduction in pituitary intensity in T1-weighted sequences in patients with obesity. ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37479795; info:eu-repo/semantics/altIdentifier/wos/WOS:001035565900001; volume:47; firstpage:948; lastpage:955; numberofpages:8; journal:INTERNATIONAL JOURNAL OF OBESITY; https://hdl.handle.net/11573/1687795 |
| DOI: |
10.1038/s41366-023-01338-w |
| Availability: |
https://hdl.handle.net/11573/1687795; https://doi.org/10.1038/s41366-023-01338-w |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.1D950A06 |
| Database: |
BASE |