Combined portal and hepatic vein embolisation in perihilar cholangiocarcinoma
| Title: | Combined portal and hepatic vein embolisation in perihilar cholangiocarcinoma |
|---|---|
| Authors: | Smits J; Chau S; James S; Korenblik R; Tschogl M; Arntz P; Bednarsch J; Abreu de Carvalho L; Detry O; Erdmann J; Gruenberger T; Hermie L; Neumann U; Sandstrom P; Sutcliffe R; Denys A; Melloul E; Dewulf M; van der Leij C; Chevallier P; Wigmore S; Newhook T; Vauthey J-N; Memeo R; Dasari BV; Braunwarth E; Aldrighetti L; van Baardewijk L; Barbier L; Binkert C; Bjornsson B; Andorra EC; Arslan B; Baclija I; Bemelmans M; Bent C; de Boer MT; Bokkers RPH; de Boo D; Breen D; Breitenstein S; Bruners P; Cappelli A; Carling U; Casellas i Robert M; Chan B; De Cobelli F; Cha C; Choi J; Crawford M; Croagh D; van Dam R; Deprez F; Diaz-Nieto R; Dili A; Erdmann JI; Font JC; Davis R; Delle M; Fernando R; Fouraschen S; Fretland AA; Fundora Y; Gelabert A; Gerard L; Gobardhan P; Gomez F; Guiliante F; Grochola LF; Grunhagen D; Gimenez JG; Hagendoorn J; Heil J; Heise D; Herrero E; Hess G; Hilal MA; Hoffmann M; Iezzi R; Imani F; Inmutto N; Garcia Borobia FJ; Jovine E; Kalil J; Kingham P; Clarunis OK; Kleeff J; Lopez-Ben S; Macdonald A; Meijerink M; Lapisatepun W; Leclercq W; Lindsay R; Lucidi V; Madoff DC; Martel G; Mehrzad H; Menon K; Metrakos P; Modi S; Moelker A; Montanari N; Moragues JS; Lopez JN; Nguyen J; Peddu P; Primrose J; Damink SO; Qu X; Raptis DA; Ratti F; Ryan S; Ridouani F; Borel Rinkes IHM; Rogan C; Ronellenfitsch U; Serenari M; Salik A; Sallemi C; Martin ES; Sarria L; Schadde E; Serrablo A; Settmacher U; Smits M; Snitzbauer A; Soonawalla Z; Sparrelid E; Spuentrup E; Stavrou G; Tancredi I; Tasse JC; Teichgraber U; Udupa V; Valenti DA; Vass D; Vogl T; Wang X; White S; De Wispelaere J-F; Wohlgemuth W; YU D; Zijlstra I |
| Source: | HPB, 2024 |
| Publisher Information: | Elsevier B.V. |
| Publication Year: | 2024 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | © 2024 The AuthorsBackground: Major hepatectomy in perihilar cholangiocarcinoma (pCCA) patients with a small future liver remnant (FLR) risks posthepatectomy liver failure (PHLF). This study examines combined portal and hepatic vein embolisation (PVE/HVE) to increase preoperative FLR volume and potentially decrease PHLF rates. Methods: In this retrospective, multicentre, observational study, data was collected from centres affiliated with the DRAGON Trials Collaborative and the EuroLVD registry. The study included pCCA patients who underwent PVE/HVE between July 2016 and January 2023. Results: Following PVE/HVE, 28% of patients (9/32) experienced complications, with 22% (7/32) necessitating biliary interventions for cholangitis. The median degree of hypertrophy after a median of 16 days was 16% with a kinetic growth rate of 6.8% per week. 69% of patients (22/32) ultimately underwent surgical resection. Cholangitis after PVE/HVE was associated with unresectability. After resection, 55% of patients (12/22) experienced complications, of which 23% (5/22) were Clavien-Dindo grade III or higher. The 90-day mortality after resection was 0%. Conclusion: PVE/HVE quickly enhances the kinetic growth rate in pCCA patients. Cholangitis impairs chances on resection significantly. Resection after PVE/HVE is associated with low levels of 90-day mortality. The study highlights the potential of PVE/HVE in improving safety and outcomes in pCCA undergoing resection. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/301179; https://eprints.ncl.ac.uk/fulltext.aspx?url=301179/EB358A11-4B26-49A0-BB34-01DBEE234221.pdf&pub_id=301179 |
| Availability: | https://eprints.ncl.ac.uk/301179 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.1DC51EF1 |
| Database: | BASE |