| Title: |
Simvastatin in Critically Ill Patients with Covid-19. |
| Authors: |
REMAP-CAP Investigators; Hills, Thomas E; Lorenzi, Elizabeth; Berry, Lindsay R; Shyamsundar, Murali; Al-Beidh, Farah; Annane, Djillali; Arabi, Yaseen; Aryal, Diptesh; Au, Carly; Beane, Abigail; Bhimani, Zahra; Bonten, Marc; Bradbury, Charlotte A; Brunkhorst, Frank M; Burrell, Aidan; Buxton, Meredith; Calfee, Carolyn S; Cecconi, Maurizio; Cheng, Allen C; Cove, Matthew E; Detry, Michelle A; Estcourt, Lise J; Fitzgerald, Mark; Goligher, Ewan C; Goossens, Herman; Green, Cameron; Haniffa, Rashan; Harrison, David A; Hashmi, Madiha; Higgins, Alisa M; Horvat, Christopher; Huang, David T; Ichihara, Nao; Jayakumar, Deva; Kruger, Peter S; Lamontagne, François; Lampro, Lamprini; Lawler, Patrick R; Marshall, John C; Mason, Alexina J; McGlothlin, Anna; McGuinness, Shay; McQuilten, Zoe K; McVerry, Bryan J; Mouncey, Paul R; Murthy, Srinivas; Neal, Matthew D; Nichol, Alistair D; O'Kane, Cecilia M; Parke, Rachael L; Parker, Jane C; Rabindrarajan, Ebenezer; Reyes, Luis F; Rowan, Kathryn M; Saito, Hiroki; Santos, Marlene; Saunders, Christina T; Seymour, Christopher W; Shankar-Hari, Manu; Sinha, Pratik; Thompson, B Taylor; Turgeon, Alexis F; Turner, Anne M; van de Veerdonk, Frank; Weis, Sebastian; Young, Ian S; Zarychanski, Ryan; Lewis, Roger J; McArthur, Colin J; Angus, Derek C; Berry, Scott M; Derde, Lennie PG; Webb, Steve A; Gordon, Anthony C; McAuley, Daniel F |
| Publisher Information: |
Massachusetts Medical Society; //doi.org/10.1056/nejmoa2309995; N Engl J Med |
| Publication Year: |
2023 |
| Collection: |
Apollo - University of Cambridge Repository |
| Subject Terms: |
Humans; Bayes Theorem; COVID-19; COVID-19 Drug Treatment; Critical Illness; Hospital Mortality; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Simvastatin; Treatment Outcome |
| Description: |
BACKGROUND: The efficacy of simvastatin in critically ill patients with coronavirus disease 2019 (Covid-19) is unclear. METHODS: In an ongoing international, multifactorial, adaptive platform, randomized, controlled trial, we evaluated simvastatin (80 mg daily) as compared with no statin (control) in critically ill patients with Covid-19 who were not receiving statins at baseline. The primary outcome was respiratory and cardiovascular organ support-free days, assessed on an ordinal scale combining in-hospital death (assigned a value of -1) and days free of organ support through day 21 in survivors; the analyis used a Bayesian hierarchical ordinal model. The adaptive design included prespecified statistical stopping criteria for superiority (>99% posterior probability that the odds ratio was >1) and futility (>95% posterior probability that the odds ratio was |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://www.repository.cam.ac.uk/handle/1810/363268; https://doi.org/10.17863/CAM.105415 |
| DOI: |
10.17863/CAM.105415 |
| Availability: |
https://www.repository.cam.ac.uk/handle/1810/363268; https://doi.org/10.17863/CAM.105415 |
| Rights: |
Attribution-NoDerivatives 4.0 International ; https://creativecommons.org/licenses/by-nd/4.0/ |
| Accession Number: |
edsbas.1DC918FD |
| Database: |
BASE |