| Title: |
Gender differences in depression, anxiety, and quality of life in Parkinson’s disease before and after deep brain stimulation surgery: a multicentre cohort study |
| Authors: |
Abbott, MG; Ahmed, A; Pavese, N; Macerollo, A; Newman, EJ; Farah, JO; Sarangmat, N; Misbahuddin, A; Ledingham, D; GIbbs, M; Mills, R; Ashkan, K; Silverdale, M; Samuel, M; Okai, D; Shotbolt, P |
| Publisher Information: |
BMJ |
| Publication Year: |
2025 |
| Collection: |
The University of Liverpool Repository |
| Description: |
Background Disproportionately fewer females with Parkinson’s disease (PD) undergo deep brain stimulation surgery (DBS). Some data show worse depression, anxiety, and quality of life (QOL) in females with PD. Investigations into these gender disparities, or the effect of DBS on these non-motor symptoms, remain limited. Methods 61 PD patients across seven UK DBS centres were recruited for the Clinical Response of Impulsive behaviours to deep brain Stimulation in PD (CRISP) prospective cohort study. Questionnaires measured primary outcomes of depression (Patient Health Questionnaire-9), anxiety (Generalised Anxiety Disorder-7) and QOL (Parkinson’s Disease Questionnaire-39) before and 6months after bilateral subthalamic nucleus DBS, and secondary outcomes of predictors of postoperative changes in mood. Results Females were disproportionately under-referred for DBS (28% of cohort). Baseline depression and anxiety were similar between genders. While DBS significantly improved overall anxiety (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
2632-6140 |
| Relation: |
https://livrepository.liverpool.ac.uk/3194804/1/Revised%20manuscript%20with%20figures.docx; Collapse authors list. Abbott, MG orcid:0009-0009-8072-7018 , Ahmed, A orcid:0009-0005-9555-8721 , Pavese, N, Macerollo, A orcid:0000-0003-4322-2706 , Newman, EJ orcid:0000-0002-4456-7389 , Farah, JO, Sarangmat, N, Misbahuddin, A, Ledingham, D, GIbbs, M et al (show 6 more authors) , Mills, R, Ashkan, K, Silverdale, M, Samuel, M, Okai, D and Shotbolt, P orcid:0000-0001-8868-837X (2025) Gender differences in depression, anxiety, and quality of life in Parkinson’s disease before and after deep brain stimulation surgery: a multicentre cohort study BMJ Neurology Open, 7 (2). e001246-. ISSN 2632-6140, 2632-6140 |
| DOI: |
10.1136/bmjno-2025-001246 |
| Availability: |
https://livrepository.liverpool.ac.uk/3194804/; https://doi.org/10.1136/bmjno-2025-001246; https://livrepository.liverpool.ac.uk/3194804/1/Revised%20manuscript%20with%20figures.docx |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.1DE80359 |
| Database: |
BASE |