| Title: |
Preferential Targeting of Conserved Gag Regions after Vaccination with a Heterologous DNA prime - Modified Vaccinia Ankara (MVA) boost HIV-1 vaccine regimen |
| Authors: |
Bauer, A; Podola, L; Mann, P; Missanga, M; Haule, A; Sudi, L; Nilsson, C; Kaluwa, B; Lueer, C; Mwakatima, M; Munseri, PJ; Maboko, L; Robb, ML; Tovanabutra, S; Kijak, G; Marovich, M; McCormack, S; Joseph, S; Lyamuya, E; Wahren, B; Sandström, E; Biberfeld, G; Hoelscher, M; Bakari, M; Kroidl, A; Geldmacher, C |
| Source: |
Journal of Virology , 91 (18) , Article e00730-17. (2017) |
| Publication Year: |
2017 |
| Collection: |
University College London: UCL Discovery |
| Description: |
Prime-boost vaccination strategies against HIV-1 often include multiple variants for a given immunogen for better coverage of the extensive viral diversity. To study the immunologic effects of this approach, we characterized breadth, phenotype, function and specificity of Gag-specific T cells induced by a DNA-prime Modified Vaccinia Ankara (MVA)-boost vaccination strategy, which uses mismatched Gag immunogens in the TamoVac 01 phase IIa trial. Healthy Tanzanian volunteers received three injections of the DNA-SMI vaccine encoding for a subtype B and AB-recombinant Gagp37 and two vaccinations with MVA-CMDR encoding subtype A Gagp55 Gag-specific T-cell responses were studied in 42 vaccinees using fresh peripheral blood mononuclear cells. After the first MVA-CMDR boost, vaccine-induced IFN-γ(+) Gag-specific T cell responses were dominated by CD4(+) T cells (compared to CD8(+) T cells, p |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/1566502/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/1566502/1/McCormack_J.%20Virol.-2017-Bauer-JVI.00730-17.pdf; https://discovery.ucl.ac.uk/id/eprint/1566502/ |
| Rights: |
open |
| Accession Number: |
edsbas.1E074D66 |
| Database: |
BASE |