| Title: |
Intra-erythrocyte creatine, plasma creatine and long-term outcomes in stable kidney transplant recipients:Results from the TransplantLines Biobank and Cohort study |
| Authors: |
Doorenbos, Caecilia S.E.; Post, Adrian; van der Veen, Yvonne; Franssen, Casper F.M.; Eisenga, Michele F.; Dullaart, Robin P.F.; Navis, Gerjan; Wu, Qinglin; Gonzalez-Delgado, Jessica M.; Connelly, Margery A.; Bakker, Stephan J.L. |
| Source: |
TransplantLines Investigators, Doorenbos, C S E, Post, A, van der Veen, Y, Franssen, C F M, Eisenga, M F, Dullaart, R P F, Navis, G, Wu, Q, Gonzalez-Delgado, J M, Connelly, M A & Bakker, S J L 2026, 'Intra-erythrocyte creatine, plasma creatine and long-term outcomes in stable kidney transplant recipients : Results from the TransplantLines Biobank and Cohort study', Clinical Nutrition Open Science, vol. 65, 100606. https://doi.org/10.1016/j.nutos.2025.11.013 |
| Publication Year: |
2026 |
| Collection: |
University of Groningen research database |
| Subject Terms: |
Creatine; Erythrocytes; Erythropoiesis; Graft-failure; Kidney transplantation; Mortality |
| Description: |
Introduction: Kidney transplant recipients (KTR) have excess mortality compared to the general population and show altered creatine homeostasis. Creatine, an endogenous nitrogenous compound, is essential for energy metabolism. We investigated determinants of circulating creatine and their sex-specific associations with mortality in KTR. Methods: Intra-erythrocyte and plasma creatine were quantified by nuclear magnetic resonance in samples from KTR and living kidney donors (healthy controls) from the TransplantLines Biobank and Cohort study (ClinicalTrials.gov: NCT03272841). Determinants of intra-erythrocyte and plasma creatine were assessed using linear regression; associations with mortality were evaluated with Cox regression. Results: 815 KTR and 53 healthy controls were included. Compared with controls, KTR had higher intra-erythrocyte but lower plasma creatine, with women having higher concentrations of each in both groups. In KTR, plasma creatine, BMI, erythrocyte count, reticulocyte count, lactate dehydrogenase, and erythropoietin use were positively associated with intra-erythrocyte creatine, whereas hemoglobin, haptoglobin, ferritin, transferrin saturation, proliferation inhibitor use were negatively associated. In univariable analyses, higher intra-erythrocyte creatine was associated with higher risk of mortality in male KTR (HR: 2.30 (1.50; 3.54), P |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
2667-2685 |
| Relation: |
info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/9f009c21-3f60-4b7c-b6cb-6b49fb0e6222; info:eu-repo/semantics/altIdentifier/pissn/2667-2685 |
| DOI: |
10.1016/j.nutos.2025.11.013 |
| Availability: |
https://hdl.handle.net/11370/9f009c21-3f60-4b7c-b6cb-6b49fb0e6222; https://research.rug.nl/en/publications/9f009c21-3f60-4b7c-b6cb-6b49fb0e6222; https://doi.org/10.1016/j.nutos.2025.11.013; https://pure.rug.nl/ws/files/1503274871/1-s2.0-S2667268525001330-main.pdf; https://www.scopus.com/pages/publications/105025575111 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.1E312CE6 |
| Database: |
BASE |