| Title: |
Oral anticoagulant safety in family practice: prognostic accuracy of Bleeding Risk Scores (from the CACAO study) |
| Authors: |
Gaboreau, Yoann; Frappé, Paul; Vermorel, Céline; Foote, Alison; Bosson, Jean-Luc; Pernod, Gilles; Abenhaïm, Nathan; Ackermann, Sophie; Blanpain, Maryse Adam; Andreu, Xavier; Arnould, Céline; Atlan-Cottin, Audrey; Aubert, Jean-Pierre; Aubin-Auger, Isabelle; Aubry, Jacques; Augueux, Julien; Augustin, Veena; Bakry, Annick; Baldesi, Marine; Banoun, Eric; Barberet, Eric; Bardet, Rémi; Barriere, Florence; Baruch, Dan; Baude, Nicolas; Bayen, Marc; Bayen, Sabine; Bayle, François; Beaufils, Yannick; Beaupin, Alain; Bedel-Chauvaud, Julie; Bel, Raphaël; Bellier, Martine; Bendamene, Farouk; Berard, Philippe; Berbé, Cédric; Berkhout, Christophe; Berland, Jacques; Béthembos, Charles-Edouard; Billiard, Pierre-Yves; Bisch, Olivier; Bizeau, Aurélie; Blanchard, Paul; Blanquart, Guy; Boch, Aurélie; Bodein, Isabelle; Boige, Emmanuel; Bonin, Claude; Bonis, Anne-Laure; Bonnard, Marie-Pierre; Bonnet, Pascal; Bonnet, Pierre-André; Bosselut, Gérard; Bottet, Anne; Bouche, Philippe; Boucherle, Bérengère; Bougeard, Audrey; Bouhana, Serge; Boukeloul, Mourad; Boulet-Gercourt, Jean; Boulongne, Jean-Marie; Bouniol, Lionel; Bourcart, Jean-Jacques; Bourgoin, Michel; Bourguignon-Vartanian, Véronique; Bouteville, Claire; Boutin, Philippe; Boutmy, Annelore; Brenner-Girault, Evelyne; Breton, Nicolas; Briane-Fraysse, Muriel; Brodbeck, Marina; Brunet, Olivier; Buchinger, Ariel; Buffaz-Sutra, Anne; Bur, Marc; Cabourdin, Philippe; Cachera, Philippe; Cailliez, Eric; Calafiore, Matthieu; Calvet, Denis; Camedescasse, Pierre; Canart, Hervé; Cancade, Michel; Candelier, Christophe; Capiod, Christian; Carin, Thierry; Caron, Olivier; Carré, Elisa; Carrillo, Yannick; Casagrande, Nathalie; Causse, Pierre; Chabert, Gaëlle; Chabord, Frédérick; Chambe, Juliette; Chambon, Guillaume; Champeaux, Richard; Charbonnel, Laurent; Charles, Rodolphe; Charra, Clément; Chartier, Samuel; Chastang, Julie; Chatelard, Sophia; Chatillon, Eric; Chauvot, Laurent; Chelle, Hervé; Chenuet, Stéphane; Chevalier, Nicolas; Chevillot, David; Cibeer, Jean-Pierre; Cittée, Jacques; Claudel, Jean-François; Clemence, Yvonnick; Clerget, Jean-Paul; Clusier-Jeudy, Isabelle; Coispeau, Marie-Pierre; Colin, Arnaud; Collart-Dutilleul, Hervé; Compagnon, Laurence; Compan Malet, Marine; Connan, Laurent; Conrad, Hubert; Coquillaud, Bruno; Cormier, Jean-Luc; Couette, Jean-Charles; Cournoyer, Yves; Cousin, Christian; Creton, Stephen; Crignon, Jean-Jacques; Cros, André; Cunin, Michel; Cussac, Emmanuel; Dailly, Jean-Maurice; Danvin, Didier; Darnaut, Pierre-Marie; Daubin, Bruno; de L’hamaide, Thomas; de Saint Meleuc, Yves; de Taddeo, Sabine; Decker, Jean-Luc; Decobert, Anne; Delattre, Yannick; Delavenne, Christine; Delavenne, Loïc; Delbru, Bénédicte; Deleplanque, Denis; Delerive, Nicole; Delesalle, Laurent; Delforge, François; Delgrange, Jean-Paul; Delpierre, Jean-Pierre; Demeulemeester, Eric; Derain, Nicolas; Descombe, Fabrice; Desmoulins, Thierry; Deville-Carollo, Marie-Claire; Dherbecourt, Jean-Michel; Didierjean, Michael; Domrane, Salima; Douzou, Brigitte; Druart, Sabine; Dubeau, Xavier; Dubedat, Arnaud; Dudragne, Résika; Duez, Christian; Dufour, Lucien; Duhamel, Sylvie; Duisit, Lionel; Dumoitier, Nathalie; Dumond, Hervé; Dumortier, Julien; Duquesne, Emilie; Durand, David; Durieux, William; Durot, Philippe; Duss, Taous; Eschalier, Bénédicte; Espiard, Eric; Eterstein, Pierre; Etienney, Joël; Faidix, Xavier; Famery, Patrice; Faria, David; Faure, Renaud; Ferrer, André; Ferrer, Jean-Marie; Feuillet, Jean; Fivel, Christian; Flaissier, Christian; Fortané, Julien; Forté, Jenny; Fossé, Claude; Foucat, Joël; Fouillard, Christophe; Fournier, Vianney; Fournier, Virginie; Fraizy, Déborah; Frenoy-Sansarricq, Isabelle; Gabbai, Bernard; Gaillard, Fabien; Garnier, Isabelle; Garnier, Jean-Michel; Gascoin, Jean-Claude; Gault, Yves; Gaultier, Martine; Gay, Bruno; Gédon, Benoît; Genies, Christophe; Géniole, Jean-Marc; Gentner, Jean-Luc; Ghez, Jean-Louis; Giraldi, Charles; Girard, Christian; Giraud, Philippe; Godart, Sylvain; Goidin, Pierre; Gomez, Aline; Goncalves, Céline; Gouget, Arnaud; Gouget, Marie-Laure; Gournay, Sylvain; Grand, Florence; Granier, Jean-Claude; Greffe, Roland; Grutter, Sabine; Gryb, Catherine; Guedel, François-Xavier; Guérin, Mathieu; Guiberteau, Julien; Guille, Jean-François; Guillot, Jean-Pierre; Guillou, Philippe; Gustin, Gilles; Guyot, Anne; Guyot, Jean-Marie; Hardy, Christophe; Hassid, David; Hayani, Latifa; Heller, Anne; Henriot, Frédéric; Hermouet, Thierry; Hoenner Hecht, Bénédicte; Honvoh Senadjro, Ferreol; Houdard, Gaëtan; Huas-Suarez, Isabelle; Huber, Corinne; Imbert, Patrick; Jacques, Pascal; Jacquet, Cécile; Jacquet, Jean-Pierre; Jacquiot, Denis; Jacquot, Philippe; Jaffre, Samy; Jean, Clémence; Jeanmougin, Pauline; Jeudy, Isabelle; Joseph, Jean-Philippe; Jouannic, Pierre; Jousson, Stéphanie; Kastelik, André; Klifa, Gérard; Knockaert, François-René; Koch, Jean-Philippe; Krotoff, Julia; Labrune, Charlotte; Lacaille-Smerilli, Véronique; Lacoin, François; Lainé, Xavier; Lambert, Philippe; Lambourg, Audrey; Lamy, Dominique; Lapenne-Creusot, Myriam; Laporte, Jean-Dominique; Lartaud, Lucie; Lauchet, Nadège; Lavielle, Dorothée; Le Breton, Julien; Le Diagon, Raphaël; Le Du, Marie; Le Goff, Delphine; Le Lann, Claire; Le Mouël, Stéphane; Leblan-Depelsenaire, Carole; Leclercq, Frédéric; Lécutier, Rudolphe; Ledoux, Jean-Nicolas; Lefebvre, Jean-Marc; Léger, Pascal; Lendais, Robert; Lengagne, Eric; Sosiewicz-Lengsavath, Catherine; Lenoir, Sylvie; Lerouge, Patrick; Leroy, Benoît; Leung-Y-Tai, Ida; Ligier, Pascal; Lobel, Charlotte; Loez, François; Lognos, Béatrice; Luaces, Baptiste; Lucas-Couturier, Laurence; Lunven, Anne; Machraoui, Sigolène; Maciejewski, André; Magnen, Loïc; Makridis, Georgios; Malbrunot, Jean-Luc; Mancini, Jean-Marc; Mangin, Hervé; Maniglier, Jean-Marc; Marchant, Philippe; Marcus, Julie; Marien, Guillaume; Martin-Etzol, Anne-Laure; Mas, Christian; Masset, Yannick; Massin, Pierre; Masson, Bruno; Mattera, Agnès; Matz, Charlotte; Maufoy, François; Maury, Collette; Mavraganis, Laure-Emmanuelle; Mazin, Olivier; Mazué, Lison; Melizan, Jean-Philippe; Menard, Dominique; Mercier, Alain; Mercier, Patricia; Meyer, Patric-Alain; Michellier, Philippe; Milleret, Corinne; Millot, Yannick; Minard, Françoise; Miqueu, Marie-Léa; Mismacque, Dany; Mitifiot, Catherine; Moebs, Jean-Louis; Monnier, Jean-Michel; Montariol, Yves; Montauze, Jérémie; Morand, Alain; Morel, Gilles; Morlon, François; Mortas, Delphine; Motte, Baptiste; Mouget, Stéphane; Munro, Luc; Naessens, Martin; Nammathao, Bounthanousone; Negre, Dominique; Nogrel, Charlie; Nouvellet, Lucile; Nureni Banafunzi, Ismaël; Oger, Thierry; Ortholan, Jean-François; Osty, Dominique; Oude Engberink, Agnès; Paillard, Guy-Marc; Paillard, Laurent; Pautout-Guillaume, Marie-Paule; Pech-Gourg, Laurent; Perdrix, Corinne; Perez, Véronique; Perrillat-Amédé, Ségolène; Peyrou, Christophe; Pichat, Bruno; Pigache, Christophe; Pinot, Alexis; Piquard, Dominique; Piquet, Thierry; Placet, Michel; Plauchier, Michel; Pluskota, Caroline; Ponchant, Maurice; Prat, Chantal; Prevost, Martine; Prigent, Jean-Pierre; Py, Thibaut; Rafin, Christian; Rambaud, Jacques; Rapoud, Jean-Paul; Regnier, Anne-Marie; Renaudin, Sylvain; Rétaux, Jean-Michel; Richard, Amélie; Richetta, Philippe; Rigault, Jean-Michel; Rigoli, Reinold; Ritter-Meinicke, Anne; Robert, Sarah; Rollin, Stéphanie; Rondepierre, Didier; Rosenberg, Sophie; Roth, Mélanie; Rougerie, Fabien; Royer de Vericourt, Guillaume; Rudelle, Karen; Ruelle, Philippe; Ruetsch, Marcel; Saillard, Dominique; Saint-Denis, Pénélope; Sannelli, Pietro; Saraidarian, Philippe; Sastourné, Jean-Pascal; Sauvage, Laurent; Scellier, Christian; Schaal, Christian; Schelcher, François-Xavier; Schirlin, Daniel; Schirrer, Anne; Schlienger, Claude; Schlienger, Joëlle; Serayet, Philippe; Serramoune, Denis; Siebler, Marlène; Simon, Jean-Paul; Soares, André; Soussotte-Ducasse, Carine; Stefanuto, Philippe; Steinberger, Marc; Szapiro, Marianne; Taha, Anas; Taluy, Erol; Tanguy, Gilles; Tardieux, Dominique; Tardy, Michel; Tavernier, Benoît; Ténédos, Jean-Luc; Thelot-Bach, Lorène; Tisserand, Rémy; Tordoir, Audrey; Trillot, François; Triouleyre, Pascal; Truong, David; Turi, Laurent; Vaillant, Frédéric; Vaillant-Roussel, Hélène; Vailler, Pierre; Vallee, Josette; Vampouille, Muriel; Vangi, Jean-Louis; Vannier, Fabien; Varin, Simon; Vaugeois, Florence; Vauthier, Jean-Charles; Vauthier, Virginie; Veillard, Delphine; Verjus, Anne-Laure; Verjus, Paul-Bernard; Verney, Gilles; Vialtel, Eloïse; Vierling, Fernand; Virgone-Rebaud, Graziella; Vital-Durand, Marc; Vittori, Eric; Volcler, Nadège; Vorilhon, Philippe; Watteau, Pierre; Weisbecker, Christine; Wey, Nathalie; Wilhelm-Nenot, Françoise; Wurtz, Jean-Louis; Yvon, Patricia; Zabawa, Claire; Zamboni, Jean-Marc; Zipper, Anne-Claire |
| Contributors: |
Modélisation et Évaluation des données complexes en Santé Publique (TIMC-MESP); Translational Innovation in Medicine and Complexity / Recherche Translationnelle et Innovation en Médecine et Complexité - UMR 5525 (TIMC); VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP); Université Grenoble Alpes (UGA)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP); Université Grenoble Alpes (UGA); Santé Ingénierie Biologie Saint-Etienne (SAINBIOSE); Centre Ingénierie et Santé (CIS-ENSMSE); École des Mines de Saint-Étienne (Mines Saint-Étienne MSE); Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE); Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM); Centre d'Investigation Clinique - Epidémiologie Clinique CHU Saint-Etienne (CIC-EC 1408); Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM); CHU de Grenoble-Alpes - Centre Hospitalier Universitaire CHU Grenoble (CHUGA); F-Crin INvestigation Network On Venous Thrombo-Embolism CHU Saint-Etienne (Innovte); Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E); Procédés Alimentaires et Microbiologiques Dijon (PAM); Université de Bourgogne (UB)-Université Bourgogne Franche-Comté COMUE (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Dijon; Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro); Aliment, Fermentation, Interaction, Microbiote (AFIM); Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Bourgogne (UB)-Université Bourgogne Franche-Comté COMUE (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Dijon; Antibioclic Paris, France; Université Paris Cité (UPCité); Université de Nantes (UN); Direction de la Recherche Clinique et de l’Innovation CHU Clermont-Ferrand (DRCI); CHU Clermont-Ferrand; Département de Médecine Générale Clermont-Ferrand; Faculté de Médecine - Clermont-Auvergne (FM - UCA); Université Clermont Auvergne 2017-2020 (UCA 2017-2020 )-Université Clermont Auvergne 2017-2020 (UCA 2017-2020 ); AutomédiCation aCcompagnement Pluriprofessionnel PatienT (ACCePPT); Université Clermont Auvergne 2017-2020 (UCA 2017-2020 ) |
| Source: |
ISSN: 0263-2136. |
| Publisher Information: |
CCSD; Oxford University Press (OUP): Policy B - Oxford Open Option D |
| Publication Year: |
2024 |
| Collection: |
Université Jean Monnet – Saint-Etienne: HAL |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Abstract Background To assess bleeding risk of patients treated by oral anticoagulants, several scores have been constructed to assist physicians in the evaluation of the benefit risk. Most of these scores lack a strong enough level of evidence for use in family practice. Objective To assess the predictive prognostic accuracy of 13 scores designed to assess the risk of major or clinically relevant non-major (CRNM) bleeding events in a French ambulatory cohort receiving Vitamin-K antagonists (VKA) or direct oral anticoagulants (DOACs) in a family practice setting. Methods CACAO (Comparison of Accidents and their Circumstances with Oral Anticoagulants) was a multicentre prospective cohort of ambulatory patients prescribed oral anticoagulants. We selected patients from the cohort who had received an oral anticoagulant because of non-valvular atrial fibrillation (NVAF) and/or venous thromboembolism (VTE) to be followed during one year by their GP. The following scores were calculated: mOBRI, Shireman, Kuijer, HEMORR2HAGES, ATRIA, HAS-BLED, RIETE, VTE-BLEED, ACCP score, Rutherford, ABH-Score, GARFIEL-AF, and Outcomes Registry for Better InformedTreatment of Atrial Fibrillation (ORBIT). Prognostic accuracy was assessed by using receiver operating characteristic curves and c-statistics. Results During 1 year, 3,082 patients were followed. All of the scores demonstrated only poor to moderate ability to predict major bleeding or CRNM in NVAF patients on DOACs (c-statistic: 0.41–0.66 and 0.45–0.58), respectively. The results were only slightly better for patients prescribed VKA (0.47–0.66 and 0.5–0.55, respectively) in this indication. The results were also unsatisfactory in patients treated for VTE. Conclusion None of the scores demonstrated satisfactory discriminatory ability when used in family practice. Clinical Trial Registration ClinicalTrials.gov NCT02376777 |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/fampra/cmad121 |
| Availability: |
https://hal.science/hal-04958370; https://doi.org/10.1093/fampra/cmad121 |
| Accession Number: |
edsbas.1E3651FF |
| Database: |
BASE |