Dieses Ergebnis aus BASE kann Gästen nicht angezeigt werden. Login für vollen Zugriff.

Polygenic prediction of body mass index and obesity through the life course and across ancestries

Title:	Polygenic prediction of body mass index and obesity through the life course and across ancestries
Authors:	Smit, Roelof A. J.; Wade, Kaitlin H.; Hui, Qin; Arias, Joshua D.; Yin, Xianyong; Christiansen, Malene R.; Yengo, Loic; Preuss, Michael H.; Nakabuye, Mariam; Rocheleau, Ghislain; Graham, Sarah E.; Buchanan, Victoria L.; Chittoor, Geetha; Graff, Marielisa; Guindo-Martínez, Marta; Lu, Yingchang; Marouli, Eirini; Sakaue, Saori; Spracklen, Cassandra N.; Vedantam, Sailaja; Wilson, Emma P.; Chen, Shyh-Huei; Ferreira, Teresa; Ji, Yingjie; Karaderi, Tugce; Lüll, Kreete; Machado, Moara; Malden, Deborah E.; Medina-Gomez, Carolina; Moore, Amy; Rüeger, Sina; Akiyama, Masato; Allison, Matthew A.; Alvarez, Marcus; Andersen, Mette K.; Appadurai, Vivek; Arbeeva, Liubov; Bartell, Eric; Bhaskar, Seema; Bielak, Lawrence F.; Bis, Joshua C.; Bollepalli, Sailalitha; Bork-Jensen, Jette; Bradfield, Jonathan P.; Bradford, Yuki; Brandl, Caroline; Braund, Peter S.; Brody, Jennifer A.; Broeckel, Ulrich; Burgdorf, Kristoffer S.; Cade, Brian E.; Cai, Qiuyin; Camarda, Silvia; Campbell, Archie; Cañadas-Garre, Marisa; Chai, Jin-Fang; Chesi, Alessandra; Choi, Seung Hoan; Christofidou, Paraskevi; Couture, Christian; Cuellar-Partida, Gabriel; Danning, Rebecca; Degenhardt, Frauke; Delgado, Graciela E.; Delitala, Alessandro; Demirkan, Ayşe; Deng, Xuan; Dietl, Alexander; Dimitriou, Maria; Dimitrov, Latchezar; Dorajoo, Rajkumar; Eichelmann, Fabian; Eliasen, Anders U.; Engmann, Jorgen E.; Erdos, Michael R.; Fairhurst-Hunter, Zammy; Farmaki, Aliki-Eleni; Faul, Jessica D.; Fernandez-Lopez, Juan-Carlos; Forer, Lukas; Frank, Mirjam; Freitag-Wolf, Sandra; Fritsche, Lars G.; Fuchsberger, Christian; Galesloot, Tessel E.; Gao, Yan; Geller, Frank; Giannakopoulou, Olga; Giulianini, Franco; Gjesing, Anette P.; Goel, Anuj; Gordon, Scott D.; Gorski, Mathias; Grove, Jakob; Guo, Xiuqing; Gustafsson, Stefan; Haessler, Jeffrey; Hansen, Thomas F.; Havulinna, Aki S.; Haworth, Simon J.; Heard-Costa, Nancy; Hemerich, Daiane; Highland, Heather M.; Hindy, George; Ho, Yuk-Lam; Hofer, Edith; Holliday, Elizabeth; Horn, Katrin; Hornsby, Whitney E.; Hottenga, Jouke-Jan; Huang, Hongyan; Huang, Jie; Huerta-Chagoya, Alicia; Huo, Shaofeng; Hwang, Mi Yeong; Hwu, Chii-Min; Iha, Hiroyuki; Ikeda, Daisuke D.; Isono, Masato; Jackson, Anne U.; Jansen, Iris E.; Jiang, Yunxuan; Johansson, Ingegerd; Jonsson, Anna; Jørgensen, Torben; Kalafati, Ioanna P.; Kanai, Masahiro; Kanoni, Stavroula; Kårhus, Line L.; Kasturiratne, Anuradhani; Katsuya, Tomohiro; Kawaguchi, Takahisa; Kember, Rachel L.; Kentistou, Katherine A.; Kim, Daeeun; Kim, Han-Na; Kim, Young Jin; Kleber, Marcus E.; Knol, Maria J.; Kurbasic, Azra; Lauzon, Marie; Le, Phuong; Lea, Rodney; Lee, Jong-Young; Lee, Wen-Jane; Leonard, Hampton L.; Li, Hengtong; Li, Shengchao A.; Li, Xiaohui; Li, Xiaoyin; Liang, Jingjing; Lin, Honghuang; Lin, Kuang; Liu, Jun; Liu, Xueping; Lo, Ken Sin; Long, Jirong; Lores-Motta, Laura; Luan, Jian'an; Lyssenko, Valeriya; Lyytikäinen, Leo-Pekka; Mahajan, Anubha; Malik, Md Zubbair; Mamakou, Vasiliki; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Mattheisen, Manuel; McDaid, Aaron F.; Mei, Quanshun; Meiselbach, Heike; Melendez, Tori L.; Milaneschi, Yuri; Miller, Jason E.; Millwood, Iona Y.; Mishra, Pashupati P.; Mitchell, Ruth E.; Møllehave, Line T.; Mononen, Nina; Mucha, Sören; Munz, Matthias; Mykkänen, Juha; Nakatochi, Masahiro; Nardone, Giuseppe Giovanni; Nelson, Christopher P.; Nethander, Maria; Nho, Chu Won; Nielsen, Aneta A.; Nolte, Ilja M.; Nongmaithem, Suraj S.; Noordam, Raymond; Ntalla, Ioanna; Nutile, Teresa; Pandit, Anita; Pauper, Marc; Petersen, Eva R. B.; Petersen, Liselotte V.; Piluso, Francesco; Polašek, Ozren; Poveda, Alaitz; Pyarajan, Saiju; Raffield, Laura M.; Rakugi, Hiromi; Ramirez, Julia; Rasheed, Asif; Raven, Dennis; Rayner, Nigel W.; Riveros, Carlos; Rohde, Rebecca; Ruggiero, Daniela; Ruotsalainen, Sanni E.; Ryan, Kathleen A.; Sabater-Lleal, Maria; Santin, Aurora; Saxena, Richa; Scholz, Markus; Shen, Botong; Shi, Jingchunzi; Shin, Jae Hun; Sidore, Carlo; Sidorenko, Julia; Sim, Xueling; Slieker, Roderick C.; Smith, Albert V.; Smith, Jennifer A.; Smyth, Laura J.; Southam, Lorraine; Steinthorsdottir, Valgerdur; Sun, Liang; Takeuchi, Fumihiko; Taylor, Kent D.; Tayo, Bamidele O.; Tcheandjieu, Catherine; Terzikhan, Natalie; Tesolin, Paola; Teumer, Alexander; Theusch, Elizabeth; Thompson, Deborah J.; Thorleifsson, Gudmar; Timmers, Paul R. H. J.; Trompet, Stella; Turman, Constance; Vaccargiu, Simona; van der Laan, Sander W.; van der Most, Peter J.; van Klinken, Jan B.; van Setten, Jessica; Verma, Shefali S.; Verweij, Niek; Veturi, Yogasudha; Wang, Carol A.; Wang, Chaolong; Wang, Jun-Sing; Wang, Lihua; Wang, Ya Xing; Wang, Zhe; Warren, Helen R.; Bin Wei, Wen; Wen, Wanqing; Wheeler, William A.; Wickremasinghe, Ananda R.; Wielscher, Matthias; Winsvold, Bendik S.; Wong, Andrew; Wuttke, Matthias; Xia, Rui; Yamamoto, Ken; Yang, Jingyun; Yao, Jie; Young, Hannah; Yousri, Noha A.; Yu, Lei; Zeng, Lingyao; Zhang, Weihua; Zhang, Xinyuan; Zhao, Jing-Hua; Zhao, Wei; Zhou, Wei; Zimmermann, Martina E.; Zoledziewska, Magdalena; ‘t Hart, Leen M.; Adair, Linda S.; Adams, Hieab H. H.; Aguilar-Salinas, Carlos A.; Al-Mulla, Fahd; Arnett, Donna K.; Asselbergs, Folkert W.; Åsvold, Bjørn Olav; Attia, John; Banas, Bernhard; Bandinelli, Stefania; Beilin, Lawrence J.; Bennett, David A.; Bergler, Tobias; Bharadwaj, Dwaipayan; Biino, Ginevra; Boerwinkle, Eric; Böger, Carsten A.; Borja, Judith B.; Bouchard, Claude; Bowden, Donald W.; Brandslund, Ivan; Brumpton, Ben; Buring, Julie E.; Caulfield, Mark J.; Chambers, John C.; Chandak, Giriraj R.; Chanock, Stephen J.; Chaturvedi, Nish; Ida Chen, Yii-Der; Chen, Zhengming; Cheng, Ching-Yu; Cho, Yoon Shin; Christensen, Kaare; Christophersen, Ingrid E.; Ciullo, Marina; Cole, John W.; Collins, Francis S.; Concas, Maria Pina; Cooper, Richard S.; Cruz, Miguel; Cucca, Francesco; Cutler, Michael J.; Damrauer, Scott M.; Dantoft, Thomas M.; de Borst, Gert J.; de Geus, Eco J. C.; de Groot, Lisette C. P. G. M.; De Jager, Philip L.; de Kleijn, Dominique P. V.; de Silva, H. Janaka; Dedoussis, George V.; den Hollander, Anneke I.; Du, Shufa; Easton, Douglas F.; Eckardt, Kai-Uwe; Elders, Petra J. M.; Eliassen, A. Heather; Ellinor, Patrick T.; Elmståhl, Sölve; Erdmann, Jeanette; Evans, Michele K.; Fatkin, Diane; Feenstra, Bjarke; Feitosa, Mary F.; Ferrucci, Luigi; Florez, Jose C.; Ford, Ian; Fornage, Myriam; Franke, Andre; Franks, Paul W.; Freedman, Barry I.; Gieger, Christian; Girotto, Giorgia; Golightly, Yvonne M.; Gonzalez-Villalpando, Clicerio; Gordon-Larsen, Penny; Grallert, Harald; Grant, Struan F. A.; Grarup, Niels; Griffiths, Lyn; Gudnason, Vilmundur; Haiman, Christopher; Hakonarson, Hakon; Hansen, Torben; Hartman, Catharina A.; Hattersley, Andrew T.; Hayward, Caroline; Heid, Iris M.; Heng, Chew-Kiat; Hengstenberg, Christian; Herzig, Karl-Heinz; Hewitt, Alex W.; Hishigaki, Haretsugu; Hougaard, David M.; Hoyng, Carel B.; Huang, Paul L.; Huang, Wei; Huang, Wen-Yi; Huffman, Jennifer E.; Hunt, Steven C.; Hutri, Nina; Hveem, Kristian; Hyppönen, Elina; Iacono, William G.; Ichihara, Sahoko; Ikram, M. Arfan; Isasi, Carmen R.; Jarvelin, Marjo-Riitta; Jin, Zi-Bing; Jöckel, Karl-Heinz; Jonas, Jost B.; Joshi, Peter K.; Jousilahti, Pekka; Jukema, J. Wouter; Kähönen, Mika; Kamatani, Yoichiro; Kang, Kui Dong; Kaprio, Jaakko; Kardia, Sharon L. R.; Karpe, Fredrik; Kato, Norihiro; Kavousi, Maryam; Kee, Frank; Kessler, Thorsten; Khera, Amit V.; Khor, Chiea Chuen; Kiemeney, Lambertus A. L. M.; Kim, Bong-Jo; Kim, Eung Kweon; Kim, Hyung-Lae; Kirchhof, Paulus; Kivimaki, Mika; Koh, Woon-Puay; Koistinen, Heikki A.; Kokkinos, Alexander; Kooner, Jaspal S.; Kooperberg, Charles; Kovacs, Peter; Kraaijeveld, Adriaan; Kraft, Peter; Krauss, Ronald M.; Kumari, Meena; Kutalik, Zoltan; Laakso, Markku; Lange, Leslie A.; Langenberg, Claudia; Launer, Lenore J.; Lee, Hyejin; Lee, Nanette R.; Lehtimäki, Terho; Lemaitre, Rozenn N.; Li, Huaixing; Li, Liming; Lieb, Wolfgang; Lin, Xu; Lind, Lars; Linneberg, Allan; Liu, Ching-Ti; Liu, Jianjun; Loeffler, Markus; London, Barry; Lu, Fan; Lubitz, Steven A.; Mackey, David A.; Magnusson, Patrik K. E.; Manson, JoAnn E.; Marcus, Gregory M.; Marques Vidal, Pedro; Martin, Nicholas G.; März, Winfried; Matsuda, Fumihiko; McCarthy, Mark I.; McGarrah, Robert W.; McGue, Matt; McKnight, Amy Jayne; Medland, Sarah E.; Mellström, Dan; Metspalu, Andres; Mitchell, Braxton D.; Mitchell, Paul; Mook-Kanamori, Dennis O.; Mori, Trevor A.; Morris, Andrew D.; Mucci, Lorelei A.; Munroe, Patricia B.; Nalls, Mike A.; Nazarian, Saman; Nelson, Amanda E.; Neville, Matt J.; Newton-Cheh, Christopher; Nielsen, Christopher S.; Niinikoski, Harri; Nikus, Kjell; Nöthen, Markus M.; Ogunniyi, Adesola; Ohlsson, Claes; Oldehinkel, Albertine J.; Orozco, Lorena; Pahkala, Katja; Pajukanta, Päivi; Palmer, Colin N. A.; Parra, Esteban J.; Pattaro, Cristian; Pedersen, Oluf; Pennell, Craig E.; Penninx, Brenda W. J. H.; Perusse, Louis; Peters, Annette; Peyser, Patricia A.; Porteous, David J.; Posthuma, Danielle; Power, Chris; Pramstaller, Peter P.; Province, Michael A.; Psaty, Bruce M.; Qi, Qibin; Qu, Jia; Rader, Daniel J.; Raitakari, Olli T.; Rallidis, Loukianos S.; Rao, Dabeeru C.; Redline, Susan; Reilly, Dermot F.; Reiner, Alexander P.; Rhee, Sang Youl; Ridker, Paul M.; Rienstra, Michiel; Ripatti, Samuli; Ritchie, Marylyn D.; Rivadeneira, Fernando; Roden, Dan M.; Rosendaal, Frits R.; Rotter, Jerome I.; Rudan, Igor; Rutters, Femke; Ryu, Seungho; Sabanayagam, Charumathi; Salako, Babatunde; Saleheen, Danish; Salomaa, Veikko; Samani, Nilesh J.; Sanghera, Dharambir K.; Sattar, Naveed; Schmidt, Börge; Schmidt, Helena; Schmidt, Reinhold; Schulze, Matthias B.; Schunkert, Heribert; Scott, Laura J.; Scott, Rodney J.; Sever, Peter; Sheu, Wayne H. H.; Shoemaker, M. Benjamin; Shu, Xiao-Ou; Simonsick, Eleanor M.; Sims, Mario; Singleton, Andrew B.; Sinner, Moritz F.; Smith, J. Gustav; Snieder, Harold; Spector, Tim D.; Spedicati, Beatrice; Stampfer, Meir J.; Stark, Klaus J.; Strachan, David P.; Tabara, Yasuharu; Tai, E. Shyong; Tang, Hua; Tardif, Jean-Claude; Thanaraj, Thangavel A.; Tönjes, Anke; Tuomi, Tiinamaija; Tuomilehto, Jaakko; Tusié-Luna, Maria-Teresa; van Dam, Rob M.; van der Harst, Pim; Van der Velde, Nathalie; van Duijn, Cornelia M.; van Schoor, Natasja M.; Vitart, Veronique; Vohl, Marie-Claude; Völker, Uwe; Vollenweider, Peter; Völzke, Henry; Vrieze, Scott; Wacher-Rodarte, Niels H.; Walker, Mark; Wander, Gurpreet S.; Wareham, Nicholas J.; Watanabe, Richard M.; Watkins, Hugh; Weir, David R.; Werge, Thomas M.; Widen, Elisabeth; Willemsen, Gonneke; Willett, Walter C.; Wilson, James F.; Wilson, Peter W. F.; Wong, Tien Y.; Woo, Jeong-Taek; Wright, Alan F.; Xu, Huichun; Yajnik, Chittaranjan S.; Yang, Jian; Yokota, Mitsuhiro; Yuan, Jian-Min; Zeggini, Eleftheria; Zemel, Babette S.; Zheng, Wei; Zhu, Xiaofeng; Zillikens, M. Carola; Zonderman, Alan B.; Zwart, John-Anker; null, null; Abecasis, Goncalo R.; Assimes, Themistocles L.; Auton, Adam; Boehnke, Michael; Chasman, Daniel I.; Esko, Tõnu; Stefansson, Kari; Lettre, Guillaume; Lindgren, Cecilia M.; Ng, Maggie C. Y.; O'Donnell, Christopher J.; Thorsteinsdottir, Unnur; Visscher, Peter M.; Walters, Robin G.; Winkler, Thomas W.; Wood, Andrew R.; Deloukas, Panos; Frayling, Timothy M.; Justice, Anne E.; Kilpeläinen, Tuomas O.; Locke, Adam E.; Mohlke, Karen L.; North, Kari E.; Okada, Yukinori; Willer, Cristen J.; Young, Kristin L.; Fatumo, Segun; McCaffery, Jeanne M.; Timpson, Nicholas J.; Hirschhorn, Joel N.; Sun, Yan V.; Berndt, Sonja I.; Loos, Ruth J. F.
Contributors:	Smit, Roelof A. J.; Wade, Kaitlin H.; Hui, Qin; Arias, Joshua D.; Yin, Xianyong; Christiansen, Malene R.; Yengo, Loic; Preuss, Michael H.; Nakabuye, Mariam; Rocheleau, Ghislain; Graham, Sarah E.; Buchanan, Victoria L.; Chittoor, Geetha; Graff, Marielisa; Guindo-Martínez, Marta; Lu, Yingchang; Marouli, Eirini; Sakaue, Saori; Spracklen, Cassandra N.; Vedantam, Sailaja; Wilson, Emma P.; Chen, Shyh-Huei; Ferreira, Teresa; Ji, Yingjie; Karaderi, Tugce; Lüll, Kreete; Machado, Moara; Malden, Deborah E.; Medina-Gomez, Carolina; Moore, Amy; Rüeger, Sina; Akiyama, Masato; Allison, Matthew A.; Alvarez, Marcu; Andersen, Mette K.; Appadurai, Vivek; Arbeeva, Liubov; Bartell, Eric; Bhaskar, Seema; Bielak, Lawrence F.; Bis, Joshua C.; Bollepalli, Sailalitha; Bork-Jensen, Jette; Bradfield, Jonathan P.; Bradford, Yuki; Brandl, Caroline; Braund, Peter S.; Brody, Jennifer A.; Broeckel, Ulrich; Burgdorf, Kristoffer S.; Cade, Brian E.; Cai, Qiuyin; Camarda, Silvia; Campbell, Archie; Cañadas-Garre, Marisa; Chai, Jin-Fang; Chesi, Alessandra; Choi, Seung Hoan; Christofidou, Paraskevi; Couture, Christian; Cuellar-Partida, Gabriel; Danning, Rebecca; Degenhardt, Frauke; Delgado, Graciela E.; Delitala, Alessandro; Demirkan, Ayşe; Deng, Xuan; Dietl, Alexander; Dimitriou, Maria; Dimitrov, Latchezar; Dorajoo, Rajkumar; Eichelmann, Fabian; Eliasen, Anders U.; Engmann, Jorgen E.; Erdos, Michael R.; Fairhurst-Hunter, Zammy; Farmaki, Aliki-Eleni; Faul, Jessica D.; Fernandez-Lopez, Juan-Carlo; Forer, Luka; Frank, Mirjam; Freitag-Wolf, Sandra; Fritsche, Lars G.; Fuchsberger, Christian; Galesloot, Tessel E.; Gao, Yan; Geller, Frank; Giannakopoulou, Olga; Giulianini, Franco; Gjesing, Anette P.; Goel, Anuj; Gordon, Scott D.; Gorski, Mathia; Grove, Jakob; Guo, Xiuqing; Gustafsson, Stefan; Haessler, Jeffrey; Hansen, Thomas F.; Havulinna, Aki S.; Haworth, Simon J.
Publication Year:	2025
Description:	Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the GIANT consortium and 23andMe, Inc., we developed ancestry-specific and multi-ancestry PGSs. The multi-ancestry score explained 17.6% of BMI variation among UK Biobank participants of European ancestry. For other populations, this ranged from 16% in East Asian-Americans to 2.2% in rural Ugandans. In the ALSPAC study, children with higher PGSs showed accelerated BMI gain from age 2.5 years to adolescence, with earlier adiposity rebound. Adding the PGS to predictors available at birth nearly doubled explained variance for BMI from age 5 onward (for example, from 11% to 21% at age 8). Up to age 5, adding the PGS to early-life BMI improved prediction of BMI at age 18 (for example, from 22% to 35% at age 5). Higher PGSs were associated with greater adult weight gain. In intensive lifestyle intervention trials, individuals with higher PGSs lost modestly more weight in the first year (0.55 kg per s.d.) but were more likely to regain it. Overall, these data show that PGSs have the potential to improve obesity prediction, particularly when implemented early in life.
Document Type:	article in journal/newspaper
Language:	English
Relation:	journal:NATURE MEDICINE; https://hdl.handle.net/11388/367573
DOI:	10.1038/s41591-025-03827-z
Availability:	https://hdl.handle.net/11388/367573; https://doi.org/10.1038/s41591-025-03827-z
Accession Number:	edsbas.1E46CE7A
Database:	BASE