| Title: |
Valproic Acid–induced Hepatopathy: Nine New Fatalities in Germany from 1994 to 2003 |
| Authors: |
Koenig, Stephan A.; Buesing, Deike; Longin, Elke; Oehring, Randi; Häussermann, Peter; Kluger, Gerhard; Lindmayer, Friedemann; Hanusch, Ralf; Degen, Ingrid; Kuhn, Hans; Samii, Kamrun; Jungck, Albrecht; Brückner, Reinhard; Seitz, Reinhild; Boxtermann, Wolfgang; Weber, Yvonne; Knapp, Rolf; Richard, Hans Helmut; Weidner, Birgit; Kasper, Johannes‐Martin; Haensch, Carl‐Albrecht; Fitzek, Sabine; Hartmann, Margarete; Borusiak, Peter; Müller‐Deile, Andrea; Degenhardt, Volker; Korenke, Georg‐Christoph; Hoppen, Thomas; Specht, Ulrich; Gerstner, Thorsten |
| Source: |
Epilepsia ; volume 47, issue 12, page 2027-2031 ; ISSN 0013-9580 1528-1167 |
| Publisher Information: |
Wiley |
| Publication Year: |
2006 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Summary: Purpose: Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies. We provide an update on hepatotoxic side effects in Germany between 1994 and 2003. Methods: We mailed a questionnaire to all members of the German Section of the International League Against Epilepsy, asking for VPA‐induced side effects, especially severe side effects such as hepatopathy. Results: As a result of our questionnaire, we found 31 cases of reversible hepatotoxicity and nine cases of lethal hepatopathies in Germany from 1994 to 2003. Conclusions: The outcome of patients with severe hepatotoxicity is better than that in the past. The risk of a VPA‐induced hepatopathy is not limited to patients younger than 2 years, receiving polytherapy, or patients with congenital or acquired metabolic diseases. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1111/j.1528-1167.2006.00846.x |
| Availability: |
https://doi.org/10.1111/j.1528-1167.2006.00846.x; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1528-1167.2006.00846.x; https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1528-1167.2006.00846.x |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.1E61707B |
| Database: |
BASE |