| Title: |
Surface‐Grafted Biocompatible Polymer Conductors for Stable and Compliant Electrodes for Brain Interfaces |
| Authors: |
Blau, Rachel; Russman, Samantha M; Qie, Yi; Shipley, Wade; Lim, Allison; Chen, Alexander X; Nyayachavadi, Audithya; Ah, Louis; Abdal, Abdulhameed; Esparza, Guillermo L; Edmunds, Samuel J; Vatsyayan, Ritwik; Dunfield, Sean P; Halder, Moumita; Jokerst, Jesse V; Fenning, David P; Tao, Andrea R; Dayeh, Shadi A; Lipomi, Darren J |
| Source: |
Advanced Healthcare Materials, vol 13, iss 29 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2024 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
40 Engineering (for-2020); 4016 Materials Engineering (for-2020); 4003 Biomedical Engineering (for-2020); Bioengineering (rcdc); Neurosciences (rcdc); Polymers (mesh); Biocompatible Materials (mesh); Surface Properties (mesh); Electrodes (mesh); Electric Conductivity (mesh); Brain (mesh); Brain-Computer Interfaces (mesh); Animals (mesh); Polyethylene Glycols (mesh); Gold (mesh); neural interface; PEDOT; polymer brushes; self-assembly; SI-ATRP; SI‐ATRP; self‐assembly; 0304 Medicinal and Biomolecular Chemistry (for); 0903 Biomedical Engineering (for); 1004 Medical Biotechnology (for); 3206 Medical biotechnology (for-2020) |
| Description: |
Durable and conductive interfaces that enable chronic and high-resolution recording of neural activity are essential for understanding and treating neurodegenerative disorders. These chronic implants require long-term stability and small contact areas. Consequently, they are often coated with a blend of conductive polymers and are crosslinked to enhance durability despite the potentially deleterious effect of crosslinking on the mechanical and electrical properties. Here the grafting of the poly(3,4 ethylenedioxythiophene) scaffold, poly(styrenesulfonate)-b-poly(poly(ethylene glycol) methyl ether methacrylate block copolymer brush to gold, in a controlled and tunable manner, by surface-initiated atom-transfer radical polymerization (SI-ATRP) is described. This "block-brush" provides high volumetric capacitance (120 F cm─3), strong adhesion to the metal (4h ultrasonication), improved surface hydrophilicity, and stability against 10000 charge-discharge voltage sweeps on a multiarray neural electrode. In addition, the block-brush film showed 33% improved stability against current pulsing. This approach can open numerous avenues for exploring specialized polymer brushes for bioelectronics research and application. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt8j37r484; https://escholarship.org/uc/item/8j37r484; https://escholarship.org/content/qt8j37r484/qt8j37r484.pdf |
| DOI: |
10.1002/adhm.202402215 |
| Availability: |
https://escholarship.org/uc/item/8j37r484; https://escholarship.org/content/qt8j37r484/qt8j37r484.pdf; https://doi.org/10.1002/adhm.202402215 |
| Rights: |
CC-BY |
| Accession Number: |
edsbas.1E884100 |
| Database: |
BASE |