| Title: |
Synthesis and Сytotoxicity of A-Azepanobetulinic Acid N-Methyl-Piperazinylamide |
| Authors: |
Giniyatullina, Gulnara V.; Kazakova, Oxana B.; Baikova, Irina P.; Yamansarov, Emil Yu.; Osterman, Ilya A.; Komarova, Ekaterina S.; Skvortsov, Dmitry A.; Saltikova, Irina V.; Majouga, Alexander G.; Ivanenkov, Yan A. |
| Source: |
Natural Product Communications ; volume 14, issue 7 ; ISSN 1934-578X 1555-9475 |
| Publisher Information: |
SAGE Publications |
| Publication Year: |
2019 |
| Description: |
The synthesis of A-azepanobetulinic acid N-methylpiperazinylamide was performed through a series of transformations (oximation, Beckmann rearrangement, reduction) of previously synthesized betulonic acid N-methylpiperazinylamide. In vitro cytotoxic activity was detected for the obtained compound against a number of cancer cell lines, and its potential was revealed as an antibacterial agent. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1177/1934578x19860670 |
| DOI: |
10.1177/1934578X19860670 |
| Availability: |
https://doi.org/10.1177/1934578x19860670; https://journals.sagepub.com/doi/pdf/10.1177/1934578X19860670; https://journals.sagepub.com/doi/full-xml/10.1177/1934578X19860670 |
| Rights: |
https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| Accession Number: |
edsbas.1EBA126C |
| Database: |
BASE |